The multienzyme architecture of eukaryotic fatty acid synthases

被引：147

作者：

Leibundgut, Marc ^{[1
]}

Maier, Timm ^{[1
]}

Jenni, Simon ^{[1
]}

Ban, Nenad ^{[1
]}

机构：

[1] Swiss Fed Inst Technol, Inst Mol Biol & Biophys, CH-8093 Zurich, Switzerland

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2008年 / 18卷 / 06期

基金：

瑞士国家科学基金会;

关键词：

D O I：

10.1016/j.sbi.2008.09.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Eukaryotic fatty acid synthases (FASs) are huge multifunctional enzymes that carry out all enzymatic steps essential for fatty acid biosynthesis. Recent crystallographic studies provide new insights into the architecture of the two distinct eukaryotic FAS systems, the 2.6 MDa heterododecameric fungal and the 540 kDa dimeric animal FAS. In this review, we compare the fundamentally different organization of these two megasynthases and discuss the structural principles of enzyme integration and substrate shuttling in FAS multienzymes.

引用

页码：714 / 725

页数：12

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