A limiting speed for protein folding at low solvent viscosity

被引：69

作者：

Qiu, LL ^{[1
]}

Hagen, SJ ^{[1
]}

机构：

[1] Univ Florida, Dept Phys, Gainesville, FL 32611 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 11期

关键词：

D O I：

10.1021/ja049966r

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Because protein folding dynamics are heavily overdamped, Kramers theory predicts the rate of folding to scale inversely with the reaction friction, which is usually interpreted to mean the solvent viscosity. This does not mean, however, that the speed of folding can increase without limit as solvent viscosity decreases. We show that, in a sufficiently fast-folding protein, the folding speed approaches a finite limit at low solvent viscosity, indicating a reaction controlled by internal friction. Copyright © 2004 American Chemical Society.

引用

页码：3398 / 3399

页数：2

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