Synthetic studies on halichondrins: A practical synthesis of the C.1-C.13 segment

被引：44

作者：

Stamos, DP ^{[1
]}

Kishi, Y ^{[1
]}

机构：

[1] HARVARD UNIV,DEPT CHEM & BIOL CHEM,CAMBRIDGE,MA 02138

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 48期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(96)01999-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical, scalable synthesis of the C.1-C.13 segment of halichondrin B has been developed starting from L-mannonic-gamma-lactone, using C-allylation/oxy-Michael cyclization and Ni(II)/Cr(II)-mediated vinyltrimethylsilane addition to set the C.6/C.3 and C.11 stereocenters, respectively. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：8643 / 8646

页数：4

共 17 条

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