TOTAL SYNTHESIS OF HALICHONDRIN-B FROM COMMON SUGARS - AN F-RING INTERMEDIATE FROM D-GLUCOSE AND EFFICIENT CONSTRUCTION OF THE C1 TO C21 SEGMENT

被引：45

作者：

COOPER, AJ ^{[1
]}

PAN, WX ^{[1
]}

SALOMON, RG ^{[1
]}

机构：

[1] CASE WESTERN RESERVE UNIV,DEPT CHEM,CLEVELAND,OH 44106

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 51期

关键词：

D O I：

10.1016/S0040-4039(00)61388-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An F-ring intermediate 7, with correct absolute configurations for the stereocenters at positions 17 and 20 of halichondrin B, is readily available from D-glucose. The practical utility of methoxybenzyl furanoside derivatives was demonstrated during incorporation of 7 into an acid-sensitive C1 to C21 segment.

引用

页码：8193 / 8196

页数：4

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