Inhibitors of Apoptotic Proteins: New Targets for Anticancer Therapy

被引：180

作者：

Saleem, Mohammad ^{[1
,2
]}

Qadir, Muhammad Imran ^{[1
]}

Perveen, Nadia ^{[1
]}

Ahmad, Bashir ^{[2
,4
]}

Saleem, Uzma ^{[1
,2
]}

Irshad, Tehseen ^{[3
]}

Ahmad, Bashir ^{[2
,4
]}

机构：

[1] GC Univ, Coll Pharm, Faisalabad, Pakistan

[2] Univ Punjab, Univ Coll Pharm, Lahore, Pakistan

[3] Fdn Univ Med Coll, Islamabad, Pakistan

[4] Bahauddin Zakariya Univ, Fac Pharm, Multan, Pakistan

来源：

CHEMICAL BIOLOGY & DRUG DESIGN | 2013年 / 82卷 / 03期

关键词：

baculovirus IAP repeat (BIR); BIR-containing (BIRC) proteins; inhibitors of apoptotic proteins (IAPs); DRUG-RELEASE BEHAVIOR; P(MMA/IA) HYDROGELS; METHANOLIC EXTRACT; GENE; SURVIVIN; CANCER; IAPS; DEGRADATION; EXPRESSION; CLONING;

D O I：

10.1111/cbdd.12176

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Inhibitors of apoptotic proteins (IAPs) can play an important role in inhibiting apoptosis by exerting their negative action on caspases (apoptotic proteins). There are eight proteins in this family: NAIP/BIRC1/NLRB, cellular IAP1 (cIAP1)/human IAP2/BIRC2, cellular IAP2 (cIAP2)/human IAP1/BIRC3, X-linked IAP (XIAP)/BIRC4, survivin/BIRC5, baculoviral IAP repeat (BIR)-containing ubiquitin-conjugating enzyme/apollon/BIRC6, livin/melanoma-IAP (ML-IAP)/BIRC7/KIAP, and testis-specific IAP (Ts-IAP)/hILP-2/BIRC8. Deregulation of these inhibitors of apoptotic proteins (IAPs) may push cell toward cancer and neurodegenerative disorders. Inhibitors of apoptotic proteins (IAPs) may provide new target for anticancer therapy. Drugs may be developed that are inhibiting these IAPs to induce apoptosis in cancerous cells.

引用

页码：243 / 251

页数：9

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