Fabrication of Terazocin-Loaded Poly(D,L-lactide) Microspheres by an Ultrasonic Spray Drying Method and Their Release Behaviors

被引：2

作者：

An, Guk-Hwan ^{[1
]}

Kim, Min-Jung ^{[1
]}

Lee, Hak-Jong ^{[2
]}

Park, Sang-Soo ^{[3
]}

Cho, Yong Woo ^{[1
]}

Park, Kinam ^{[4
,5
]}

Choa, Yong-Ho ^{[1
]}

机构：

[1] Hanyang Univ, Dept Fine Chem Engn, Gyeonggi Do 426791, South Korea

[2] Seoul Natl Univ, Bundong Hosp, Dept Radiol, Gyeonggi Do 463707, South Korea

[3] Eulji Univ, Dept Biomed Engn, Gyeonggi Do 461713, South Korea

[4] Purdue Univ, Dept Pharmaceut, W Lafayette, IN 47907 USA

[5] Purdue Univ, Dept Biomed Engn, W Lafayette, IN 47907 USA

来源：

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2008年 / 8卷 / 10期

关键词：

Utrasonic Spray Drying; Microspheres; Drug Delivery System; Terazocin; Poly(D; L-lactide);

D O I：

10.1166/jnn.2008.1138

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

Terazocin should be frequently administered for a long period time for the treatment of benign prostatic hyperplasia which is one of the most common diseases in elderly men. Controlled delivery of terazocin using polymer microspheres has a great potential to solve the problem. In this study, terazocin-incorporated poly(D,L-lactide) (PDLLA) microspheres were fabricated by a novel ultrasonic spray drying (USD) method, which is a rapid one-step process. The approximate diameters of microspheres were in a range of between 0.3 and 3 mu m. SEM confirmed that the microspheres had a spherical shape and narrow size distribution. FT-IR spectroscopy demonstrated that the incorporated terazocin remained intact after the USD process. The microspheres showed a fast initial burst release of terazocin within nine hours, followed by a slow but steady release for 49 days, suggesting that these microspheres are highly promising for controlled drug delivery.

引用

页码：5139 / 5142

页数：4

共 8 条

[1]

Biodegradation and biocompatibility of PLA and PLGA microspheres [J].