Biodegradable polymers and their potential use in parenteral veterinary drug delivery systems

被引:119
作者
Winzenburg, G
Schmidt, C
Fuchs, S
Kissel, T
机构
[1] Univ Marburg, Dept Pharmaceut & Biopharm, D-35032 Lahn, Germany
[2] Intervet Innovat GmbH, D-55270 Schwabenheim, Germany
关键词
biodegradable polymers; veterinary drug delivery; therapeutic applications;
D O I
10.1016/j.addr.2004.02.008
中图分类号
R9 [药学];
学科分类号
1007 [药学];
摘要
Biodegradable polymers have been extensively studied for numerous drug delivery systems for human health purposes. The ever-increasing value of animals to human society allows the application of pharmaceutical developments in the veterinary field from those developed in human medicine. Although many similarities between the human and animal health industries exist there are also notable differences. This paper provides an insight into the animal health market with regard to the challenges and special considerations associated with veterinary drug delivery. It also gives an overview of biodegradable polymers that are used or have been tested in the veterinary field. The purpose of this paper is to highlight some recent developments in this area and to investigate the directions in which veterinary pharmaceutics is heading. In particular, examples of existing biodegradable veterinary drug delivery systems are presented together with applications including intravaginal devices, injectables and implantable systems. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码:1453 / 1466
页数:14
相关论文
共 78 条
[1]
MICROPARTICLES FROM BIODEGRADABLE POLYMERS [J].
AHLERS, M ;
KRONE, V ;
WALCH, A .
ADVANCED MATERIALS, 1992, 4 (03) :230-234
[2]
Ahmed M, 2002, ADV DRUG DELIVER REV, V54, P871
[3]
Protective immunity against Salmonella typhimurium elicited in mice by oral vaccination with phosphorylcholine encapsulated in poly(DL-lactide-co-glycolide) microspheres [J].
AllaouiAttarki, K ;
Pecquet, S ;
Fattal, E ;
Trolle, S ;
Chachaty, E ;
Couvreur, P ;
Andremont, A .
INFECTION AND IMMUNITY, 1997, 65 (03) :853-857
[4]
DETERMINANTS OF RELEASE RATE OF TETANUS VACCINE FROM POLYESTER MICROSPHERES [J].
ALONSO, MJ ;
COHEN, S ;
PARK, TG ;
GUPTA, RK ;
SIBER, GR ;
LANGER, R .
PHARMACEUTICAL RESEARCH, 1993, 10 (07) :945-953
[5]
[Anonymous], ENCY CONTROLLED DRUG
[6]
Concentration of ofloxacin in canine prostate tissue and prostate: Fluid after intraprostatic injection of Biodegradable sustained-releasing microspheres containing ofloxacin [J].
Bahk, JY ;
Hyun, JS ;
Lee, JY ;
Kim, J ;
Cho, YH ;
Lee, JH ;
Park, JS ;
Kim, MO .
JOURNAL OF UROLOGY, 2000, 163 (05) :1560-1564
[7]
BARR I, 1993, INT C REG LEUK PROD
[8]
BENGS H, 1996, P INT S CONTR REL BI, V23, P114
[9]
Bowersock TL, 2000, CONTROLLED RELEASE VETERINARY DRUG DELIVERY: BIOLOGICAL AND PHARMACEUTICAL CONSIDERATIONS, P269, DOI 10.1016/B978-044482992-4/50029-0
[10]
Bunt C, 1999, P INT S CONTR REL BI, P70