Synthesis of new chiral diphosphine ligand (BisbenzodioxanPhos) and its application in asymmetric catalytic hydrogenation

被引：66

作者：

Pai, CC ^{[1
]}

Li, YM

Zhou, ZY

Chan, ASC

机构：

[1] Hong Kong Polytech Univ, Open Lab Chirotechnol, Inst Mol Technol Drug Design & Synth, Kowloon, Hong Kong, Peoples R China

[2] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 15期

关键词：

BisbenzodioxanPhos; hydrogenation; beta-keto esters; naproxen;

D O I：

10.1016/S0040-4039(02)00383-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The new chiral diphosphine ligand [(5.6) (5'.6')-bis(1.2-ethylenedioxy)biphenyl-2.2'-diyl]bis(diphenylphosphine) (Bisben-zodioxanPhos) has been successfully prepared and used in ruthenium-catalyzed asymmetric hydrogenation of 2-(6'-methoxy-2'-naphthyl)propenoic acid and beta-keto esters with high enantioselectivity (92.2% and up to 99.5% ee. respectively). (C) 2002 Published by Elsevier Science Ltd.

引用

页码：2789 / 2792

页数：4

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