Regioselective synthesis of N-alkyl pyridones

被引：32

作者：

Bowman, WR ^{[1
]}

Bridge, CF ^{[1
]}

机构：

[1] Loughborough Univ Technol, Dept Chem, Loughborough LE11 3TU, Leics, England

来源：

SYNTHETIC COMMUNICATIONS | 1999年 / 29卷 / 22期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1080/00397919908085926

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The regioselective synthesis of N-alkyl pyridones can be facilitated by alkylation of 2-methoxypyridines with activated halides. The syntheses are facile and high yielding with no traces of 2-alkoxypyridines.

引用

页码：4051 / 4059

页数：9

共 9 条

[1]

GILCHRIST T, 1997, HETEROCYCLIC CHEM, P136

[2]

JIU H, 1995, TETRAHEDRON LETT, V36, P8917

[3]

Josien H, 1998, CHEM-EUR J, V4, P67, DOI 10.1002/(SICI)1521-3765(199801)4:1<67::AID-CHEM67>3.0.CO

[4]

2-F

[5] GENERAL SYNTHETIC METHODS FOR PREPARATION OF 1-SUBSTITUTED-VINYL-2-PYRIDONES [J].

MARIANO, PS ;

KROCHMAL, E ;

BEAMER, R ;

HUESMANN, PL ;

DUNAWAYMARIANO, D .

TETRAHEDRON, 1978, 34 (17) :2609-2616

[6] PALLADIUM-CATALYZED ALLYLATION OF PYRIMIDINE-2,4-DIONES (URACILS) AND OF 6-MEMBERED HETEROCYCLIC AMBIDENT SULFUR NUCLEOPHILES [J].

MORENOMANAS, M ;

PLEIXATS, R ;

VILLARROYA, M .

TETRAHEDRON, 1993, 49 (07) :1457-1464

[7]

NAKANO H, 1992, HETEROCYCLES, V33, P195

[8] EFFECT OF MICELLES ON CYCLIZATION REACTIONS - THE USE OF N-HEXADECYL-2-CHLOROPYRIDINIUM IODIDE AS AN AMPHIPHILIC CARBOXYL-ACTIVATING AGENT IN LACTONIZATION AND LACTAMIZATION [J].

RICO, I ;

HALVORSEN, K ;

DUBRULE, C ;

LATTES, A .

JOURNAL OF ORGANIC CHEMISTRY, 1994, 59 (02) :415-420

[9]

Sato I, 1998, SYNLETT, P1308

← 1 →