Polymeric multilayer capsules for drug delivery

被引：333

作者：

De Koker, Stefaan ^{[1
,2
]}

Hoogenboom, Richard ^{[3
]}

De Geest, Bruno G. ^{[1
]}

机构：

[1] Univ Ghent, Lab Pharmaceut Technol, B-9000 Ghent, Belgium

[2] Univ Ghent, Dept Biomed Mol Biol, B-9052 Zwijnaarde, Belgium

[3] Univ Ghent, Dept Organ Chem, Supramol Chem Grp, B-9000 Ghent, Belgium

来源：

CHEMICAL SOCIETY REVIEWS | 2012年 / 41卷 / 07期

关键词：

FUNCTIONAL CORE/SHELL NANOPARTICLES; ENZYME-LOADED LIPOSOMES; BY-LAYER DEPOSITION; POLYELECTROLYTE MICROCAPSULES; CONTROLLED-RELEASE; SUSTAINED-RELEASE; COLLOIDAL PARTICLES; GOLD NANOPARTICLES; DNA ENCAPSULATION; CLICK CHEMISTRY;

D O I：

10.1039/c2cs15296g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The advent of Layer-by-Layer (LbL) assembly to fabricate polymeric as well as hybrid multilayer thin films has opened exciting avenues for the design of multifunctional drug carriers with extreme control over their physico-chemical properties. These polymeric multilayer capsules (PMLC) are typically fabricated by sequential adsorption of polymers onto a spherical substrate with dimensions varying from 10 nm to several microns and larger. In this critical review, we give an overview of the recent advances in the field of PMLC with respect to drug delivery and point out how sophisticated capsule engineering can lead to well-defined drug carriers with unique properties (139 references).

引用

页码：2867 / 2884

页数：18

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