Two Distinct Broadly Neutralizing Antibody Specificities of Different Clonal Lineages in a Single HIV-1-Infected Donor: Implications for Vaccine Design

被引：144

作者：

Bonsignori, Mattia ^{[1
]}

Montefiori, David C. ^{[1
]}

Wu, Xueling ^{[9
]}

Chen, Xi ^{[1
]}

Hwang, Kwan-Ki ^{[1
]}

Tsao, Chun-Yen ^{[1
]}

Kozink, Daniel M. ^{[1
]}

Parks, Robert J. ^{[1
]}

Tomaras, Georgia D. ^{[1
,3
]}

Crump, John A. ^{[2
,4
,6
,7
]}

Kapiga, Saidi H. ^{[8
]}

Sam, Noel E. ^{[6
]}

Kwong, Peter D. ^{[9
]}

Kepler, Thomas B. ^{[1
,5
]}

Liao, Hua-Xin ^{[1
]}

Mascola, John R. ^{[9
]}

Haynesa, Barton F. ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Duke Human Vaccine Inst, Durham, NC USA

[2] Duke Univ, Med Ctr, Dept Med, Div Infect Dis & Int Hlth, Durham, NC 27710 USA

[3] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA

[4] Duke Univ, Med Ctr, Duke Global Hlth Inst, Durham, NC 27710 USA

[5] Duke Univ, Med Ctr, Ctr Computat Immunol, Durham, NC 27710 USA

[6] Kilimanjaro Christian Med Ctr, Moshi, Tanzania

[7] Kilimanjaro Christian Med Coll, Moshi, Tanzania

[8] London Sch Hyg & Trop Med, London WC1, England

[9] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF VIROLOGY | 2012年 / 86卷 / 08期

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; HUMAN MONOCLONAL-ANTIBODY; HIV-ANTIBODIES; EPITOPE; GLYCOPROTEIN; INDIVIDUALS; BREADTH; REVEAL; GP41; PG16;

D O I：

10.1128/JVI.07163-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Plasma from a small subset of subjects chronically infected with HIV-1 shows remarkable magnitude and breadth of neutralizing activity. From one of these individuals (CH0219), we isolated two broadly neutralizing antibodies (bnAbs), CH01 and VRC-CH31, from two clonal lineages of memory B cells with distinct specificities (variable loop 1 and 2 [V1V2] conformational specificity and CD4-binding site specificity, respectively) that recapitulate 95% of CH0219 serum neutralization breadth. These data provide proof of concept for an HIV-1 vaccine that aims to elicit bnAbs of multiple specificities.

引用

页码：4688 / 4692

页数：5

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