Breadth of Human Immunodeficiency Virus-Specific Neutralizing Activity in Sera: Clustering Analysis and Association with Clinical Variables

被引：267

作者：

Doria-Rose, Nicole A. ^{[1
]}

Klein, Rachel M. ^{[1
]}

Daniels, Marcus G. ^{[4
]}

O'Dell, Sijy ^{[2
]}

Nason, Martha ^{[3
]}

Lapedes, Alan ^{[4
]}

Bhattacharya, Tanmoy ^{[4
,5
]}

Migueles, Stephen A. ^{[1
]}

Wyatt, Richard T. ^{[2
]}

Korber, Bette T. ^{[4
,5
]}

Mascola, John R. ^{[2
]}

Connors, Mark ^{[1
]}

机构：

[1] NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA

[2] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

[3] NIAID, Biostat Res Branch, NIH, Bethesda, MD 20892 USA

[4] Los Alamos Natl Lab, Los Alamos, NM 87545 USA

[5] Santa Fe Inst, Santa Fe, NM 87501 USA

来源：

JOURNAL OF VIROLOGY | 2010年 / 84卷 / 03期

基金：

美国国家卫生研究院;

关键词：

ENV CLONES; ANTIBODY-SPECIFICITIES; ELITE SUPPRESSORS; HIV-INFECTION; B-CELLS; TYPE-1; VACCINE; BROAD; SEROTYPES; IMMUNIZATION;

D O I：

10.1128/JVI.01482-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Induction of antibodies that neutralize a broad range of human immunodeficiency virus type 1 (HIV-1) isolates is a major goal of vaccine development. To study natural examples of broad neutralization, we analyzed sera from 103 HIV-1-infected subjects. Among progressor patients, 20% of sera neutralized more than 75% of a panel of 20 diverse viral isolates. Little activity was observed in sera from long-term nonprogressors (elite controllers). Breadth of neutralization was correlated with viral load, but not with CD4 count, history of past antiretroviral use, age, gender, race/ethnicity, or route of exposure. Clustering analysis of sera by a novel method identified a statistically robust subgrouping of sera that demonstrated broad and potent neutralization activity.

引用

页码：1631 / 1636

页数：6

共 35 条

[1] Maintenance of viral suppression in HIV-1-infected HLA-B*57+ elite suppressors despite CTL escape mutations [J].

Bailey, Justin R. ;

Williams, Thomas M. ;

Siliciano, Robert F. ;

Blankson, Joel N. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (05) :1357-1369

[2] Neutralizing antibodies do not mediate suppression of human immunodeficiency virus type 1 in elite suppressors or selection of plasma virus variants in patients on highly active antiretroviral therapy [J].

Bailey, Justin R. ;

Lassen, Kara G. ;

Yang, Hung-Chih ;

Quinn, Thomas C. ;

Ray, Stuart C. ;

Blankson, Joel N. ;

Siliciano, Robert F. .

JOURNAL OF VIROLOGY, 2006, 80 (10) :4758-4770

[3]

Beirnaert E, 2000, J MED VIROL, V62, P14, DOI 10.1002/1096-9071(200009)62:1<14::AID-JMV3>3.0.CO

[4]

2-L

[5] Comprehensive cross-clade neutralization analysis of a panel of anti-human immunodeficiency virus type 1 monoclonal antibodies [J].

Binley, JA ;

Wrin, T ;

Korber, B ;

Zwick, MB ;

Wang, M ;

Chappey, C ;

Stiegler, G ;

Kunert, R ;

Zolla-Pazner, S ;

Katinger, H ;

Petropoulos, CJ ;

Burton, DR .

JOURNAL OF VIROLOGY, 2004, 78 (23) :13232-13252

[6] Profiling the Specificity of Neutralizing Antibodies in a Large Panel of Plasmas from Patients Chronically Infected with Human Immunodeficiency Virus Type 1 Subtypes B and C [J].

Binley, James M. ;

Lybarger, Elizabeth A. ;

Crooks, Emma T. ;

Seaman, Michael S. ;

Gray, Elin ;

Davis, Katie L. ;

Decker, Julie M. ;

Wycuff, Diane ;

Harris, Linda ;

Hawkins, Natalie ;

Wood, Blake ;

Nathe, Cory ;

Richman, Douglas ;

Tomaras, Georgia D. ;

Bibollet-Ruche, Frederic ;

Robinson, James E. ;

Morris, Lynn ;

Shaw, George M. ;

Montefiori, David C. ;

Mascola, John R. .

JOURNAL OF VIROLOGY, 2008, 82 (23) :11651-11668

[7] HIV-1 subtype A envelope variants from early in infection have variable sensitivity to neutralization and to inhibitors of viral entry [J].

Blish, Catherine A. ;

Nedellec, Rebecca ;

Mandaliya, Kishorchandra ;

Mosier, Donald E. ;

Overbaugh, Julie .

AIDS, 2007, 21 (06) :693-702

[8] HIV vaccine design and the neutralizing antibody problem [J].

Burton, DR ;

Desrosiers, RC ;

Doms, RW ;

Koff, WC ;

Kwong, PD ;

Moore, JP ;

Nabel, GJ ;

Sodroski, J ;

Wilson, IA ;

Wyatt, RT .

NATURE IMMUNOLOGY, 2004, 5 (03) :233-236

[9] Dissecting the neutralizing antibody-specificities of broadly neutralizing sera from human immunodeficiency virus type 1-infected donors [J].

Dhillon, Amandeep K. ;

Donners, Helen ;

Pantophlet, Ralph ;

Johnson, Welkin E. ;

Decker, Julie M. ;

Shaw, George M. ;

Lee, Fang-Hua ;

Richman, Douglas D. ;

Doms, Robert W. ;

Vanham, Guido ;

Burton, Dennis R. .

JOURNAL OF VIROLOGY, 2007, 81 (12) :6548-6562

[10] Frequency and Phenotype of Human Immunodeficiency Virus Envelope-Specific B Cells from Patients with Broadly Cross-Neutralizing Antibodies [J].

Doria-Rose, Nicole A. ;

Klein, Rachel M. ;

Manion, Maura M. ;

O'Dell, Sijy ;

Phogat, Adhuna ;

Chakrabarti, Bimal ;

Hallahan, Claire W. ;

Migueles, Stephen A. ;

Wrammert, Jens ;

Ahmed, Rafi ;

Nason, Martha ;

Wyatt, Richard T. ;

Mascola, John R. ;

Connors, Mark .

JOURNAL OF VIROLOGY, 2009, 83 (01) :188-199

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