Is supercomplex organization of the respiratory chain required for optimal electron transfer activity?

被引：100

作者：

Genova, M. L. ^{[1
]}

Baracca, A. ^{[1
]}

Biondi, A. ^{[1
]}

Casalena, G. ^{[1
]}

Faccioli, M. ^{[1
]}

Falasca, A. I. ^{[2
]}

Formiggini, G. ^{[1
]}

Sgarbi, G. ^{[1
]}

Solaini, G. ^{[1
]}

Lenaz, G. ^{[1
]}

机构：

[1] Alma Mater Studiorum Univ Bologna, Dipartimento Biochim G Moruzzi, I-40126 Bologna, Italy

[2] Univ Parma, Dipartimento Sci Farmacol Biol & Chim Applicate, I-43100 Parma, Italy

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | 2008年 / 1777卷 / 7-8期

关键词：

respiratory chain; supercomplex; Coenzyme Q; cytochrome c;

D O I：

10.1016/j.bbabio.2008.04.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The supra-molecular assembly of the main respiratory chain enzymatic complexes in the form of "supercomplexes" has been proved by structural and functional experimental evidence. This evidence strongly contrasts the previously accepted Random Diffusion Model stating that the complexes are functionally connected by lateral diffusion of small redox molecules (i.e. Coenzyme Q and cytochrome c). This review critically examines the available evidence and provides an analysis of the functional consequences of the intermolecular association of the respiratory complexes pointing out the role of Coenzyme Q and of cytochrome c as channeled or as freely diffusing intermediates in the electron transfer activity of their partner enzymes. (c) 2008 Elsevier BY. All rights reserved.

引用

页码：740 / 746

页数：7

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