Liposome-Mediated Delivery of Oligodeoxynucleotides In Vivo

被引：39

作者：

Dass, Crispin R. ^{[1
]}

机构：

[1] Johnson & Johnson Res, DNAzyme Technol, Sydney, NSW 2012, Australia

来源：

DRUG DELIVERY | 2002年 / 9卷 / 03期

关键词：

Antisense; Liposome; Oligodeoxynucleotide; Oligonucleotide; Transfection;

D O I：

10.1080/15227950290097606

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Oligodeoxynuclotides (ODNs) are deoxyribonucleic-acid-based sequences showing therapeutic potential against such diseases as cancer, arteriosclerosis, arthritis, viral infections, and inflammation. Administration of these chemical entities using carriers has certain advantages over administration of free nucleic acid strands. Liposomes, one class of carriers, have been proven to be a popular choice for ODN delivery in vivo because of their potential to increase resistance of ODNs against nucleases and enhance circulation half-life. This result increases ODN uptake in target cells. Several liposomal formulations with proven potential for ODN delivery in vivo are discussed in this article.

引用

页码：169 / 180

页数：12

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