Hyaluronic acid-functionalized mesoporous silica nanoparticles for efficient photodynamic therapy of cancer cells

被引：57

作者：

Gary-Bobo, Magali ^{[2
]}

Brevet, David ^{[3
]}

Benkirane-Jessel, Nadia ^{[1
,4
]}

Raehm, Laurence ^{[3
]}

Maillard, Philippe ^{[5
,6
]}

Garcia, Marcel ^{[2
]}

Durand, Jean-Olivier ^{[3
]}

机构：

[1] Fac Med Strasbourg, INSERM UdS, Act Biomat & Tissue Engn UMR 977, F-67085 Strasbourg, France

[2] Univ Montpellier 2, Univ Montpellier 1, Fac Pharm, CNRS,Inst Biomol Max Mousseron UMR 5247, F-34093 Montpellier 05, France

[3] UM1, ENSCM, UM2, CNRS,Inst Charles Gerhardt Montpellier,UMR 5253, F-34095 Montpellier 05, France

[4] Univ Strasbourg, Fac Chirurg Dent, Strasbourg, France

[5] Univ Paris 11, Inst Curie, CNRS, UMR 176, F-91405 Orsay, France

[6] Univ Paris 11, Ctr Univ, Inst Curie, Sect Rech, F-91405 Orsay, France

来源：

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY | 2012年 / 9卷 / 03期

关键词：

Hyaluronic acid; Mesoporous silica nanoparticles; Photodynamic therapy; Layer by layer; DRUG-DELIVERY; QUANTUM DOTS; STEM-CELLS; IN-VITRO; BIODISTRIBUTION; DERIVATIVES; IMPROVE; MODEL;

D O I：

10.1016/j.pdpdt.2011.12.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Mesoporous silica nanoparticles (MSN) for photodynamic therapy (PDT) were coated with poly-(L-lysine) and hyaluronic acid (HA) by using the layer-by-layer method. HA is able to target cancer cells over-expressing the corresponding CD44 receptor. MSN functionalized with HA (MSN-HA) were more efficient than MSN without the targeting moiety when PDT was performed at low fluence (14 J cm(-2)) and low dosage of MSN (20 mu g mL(-1)) on HCT 116 colorectal cancer cells, known to over-express the CD44 receptor. Incubation of HCT-116 cancer cells with an excess of HA impaired the PDT effect with MSN-HA thus demonstrating that an active endocytosis mechanism was involved in the uptake of MSN-HA by these cells. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：256 / 260

页数：5

共 47 条

[1]

Anajwala C. C., 2010, INT J PHARM SCI NANO, V3, P1043, DOI DOI 10.37285/IJPSN.2010.3.3.2

[2]

[Anonymous], 2011, Nano Biomed. Eng, DOI DOI 10.5101/NBE.V3I2.P137-143

[3]

Nanomaterials for cancer therapy and imaging [J].

Bae, Ki Hyun ;

Chung, Hyun Jung ;

Park, Tae Gwan .

MOLECULES AND CELLS, 2011, 31 (04) :295-302

[4]

Nanomaterials: Applications in Cancer Imaging and Therapy [J].

Barreto, Jose A. ;

O'Malley, William ;

Kubeil, Manja ;

Graham, Bim ;

Stephan, Holger ;

Spiccia, Leone .

ADVANCED MATERIALS, 2011, 23 (12) :H18-H40

[5]

Nanoparticles as vehicles for delivery of photodynamic therapy agents [J].

Bechet, Denise ;

Couleaud, Pierre ;

Frochot, Celine ;

Viriot, Marie-Laure ;

Guillemin, Francois ;

Barberi-Heyob, Muriel .

TRENDS IN BIOTECHNOLOGY, 2008, 26 (11) :612-621

[6]

Nanomedicine: Application Areas and Development Prospects [J].

Boulaiz, Houria ;

Alvarez, Pablo J. ;

Ramirez, Alberto ;

Marchal, Juan A. ;

Prados, Jose ;

Rodriguez-Serrano, Fernando ;

Peran, Macarena ;

Melguizo, Consolacion ;

Aranega, Antonia .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2011, 12 (05) :3303-3321

[7]

Mannose-targeted mesoporous silica nanoparticles for photodynamic therapy [J].

Brevet, David ;

Gary-Bobo, Magali ;

Raehm, Laurence ;

Richeter, Sebastien ;

Hocine, Ouahiba ;

Amro, Kassem ;

Loock, Bernard ;

Couleaud, Pierre ;

Frochot, Celine ;

Morere, Alain ;

Maillard, Philippe ;

Garcia, Marcel ;

Durand, Jean-Olivier .

CHEMICAL COMMUNICATIONS, 2009, (12) :1475-1477

[8]

Nanoparticles in photodynamic therapy: An emerging paradigm [J].

Chatterjee, Dev Kumar ;

Fong, Li Shan ;

Zhang, Yong .

ADVANCED DRUG DELIVERY REVIEWS, 2008, 60 (15) :1627-1637

[9]

Tri-functionalization of mesoporous silica nanoparticles for comprehensive cancer theranostics-the trio of imaging, targeting and therapy [J].

Cheng, Shih-Hsun ;

Lee, Chia-Hung ;

Chen, Meng-Chi ;

Souris, Jeffrey S. ;

Tseng, Fan-Gang ;

Yang, Chung-Shi ;

Mou, Chung-Yuan ;

Chen, Chin-Tu ;

Lo, Leu-Wei .

JOURNAL OF MATERIALS CHEMISTRY, 2010, 20 (29) :6149-6157

[10]

Mesoporous silica nanoparticles functionalized with an oxygen-sensing probe for cell photodynamic therapy: potential cancer theranostics [J].

Cheng, Shih-Hsun ;

Lee, Chia-Hung ;

Yang, Chung-Shi ;

Tseng, Fan-Gang ;

Mou, Chung-Yuan ;

Lo, Leu-Wei .

JOURNAL OF MATERIALS CHEMISTRY, 2009, 19 (09) :1252-1257

← 1 2 3 4 5 →