Vascular endothelial growth factor and angiopoietins in focal cerebral ischemia

被引：190

作者：

Zhang, ZG

Chopp, M

机构：

[1] Henry Ford Hlth Sci Ctr, Dept Neurol, Detroit, MI 48202 USA

[2] Oakland Univ, Dept Phys, Rochester, MI USA

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2002年 / 12卷 / 02期

关键词：

D O I：

10.1016/S1050-1738(01)00149-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A growing body of evidence indicates that vascular growth factors and their receptors are activated after stroke, and these factors may contribute to ischemic cell damage and to angiogenesis during recovery from stroke. In this review, we focus on recent evidence for roles of vascular endothelial growth factor (VEGF) and angiopoietin 1 (Ang 1) in blood-brain barrier (BBB) leakage and angiogenesis after focal cerebral ischemia. (Trends Cardiovasc Med 2002; 12:62-66). (C) 2002, Elsevier Science Inc.

引用

页码：62 / 66

页数：5

共 54 条

[1] Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis
Adams, RH
Wilkinson, GA
Weiss, C
Diella, F
Gale, NW
Deutsch, U
Risau, W
Klein, R
[J]. GENES & DEVELOPMENT, 1999, 13 (03) : 295 - 306
[2] Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1 - A potential mechanism for vascular permeability in diabetic retinopathy and tumors
Antonetti, DA
Barber, AJ
Hollinger, LA
Wolpert, EB
Gardner, TW
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (33) : 23463 - 23467
[3] Expression of angiopoietin-1, angiopoietin-2, and tie receptors after middle cerebral artery occlusion in the rat
Beck, H
Acker, T
Wiessner, C
Allegrini, PR
Plate, KH
[J]. AMERICAN JOURNAL OF PATHOLOGY, 2000, 157 (05) : 1473 - 1483
[4] JUNCTIONS BETWEEN INTIMATELY APPOSED CELL MEMBRANES IN VERTEBRATE BRAIN
BRIGHTMA.MW
REESE, TS
[J]. JOURNAL OF CELL BIOLOGY, 1969, 40 (03) : 648 - +
[5] Molecular analysis of blood vessel formation and disease
Carmeliet, P
Collen, D
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1997, 273 (05): : H2091 - H2104
[6] Intracerebral tumor-associated hemorrhage caused by overexpression of the vascular endothelial growth factor isoforms VEGF(121) and VEGF(165) but not VEGF(189)
Cheng, SY
Nagane, M
Huang, HJS
Cavenee, WK
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (22) : 12081 - 12087
[7] Disruption of Eph/ephrin signaling affects migration and proliferation in the adult subventricular zone
Conover, JC
Doetsch, F
Garcia-Verdugo, JM
Gale, NW
Yancopoulos, GD
Alvarez-Buylla, A
[J]. NATURE NEUROSCIENCE, 2000, 3 (11) : 1091 - 1097
[8] A functional MRI study of subjects recovered from hemiparetic stroke
Cramer, SC
Nelles, G
Benson, RR
Kaplan, JD
Parker, RA
Kwong, KK
Kennedy, DN
Finklestein, SP
Rosen, BR
[J]. STROKE, 1997, 28 (12) : 2518 - 2527
[9] Criscuolo G R, 1990, Adv Neurol, V52, P469
[10] Vascular growth factors in cerebral ischemia
Croll, SD
Wiegand, SJ
[J]. MOLECULAR NEUROBIOLOGY, 2001, 23 (2-3) : 121 - 135

← 1 2 3 4 5 6 →