Sex-dependent gene expression in early brain development of chicken embryos

被引：52

作者：

Scholz, B

Kultima, K

Mattsson, A

Axelsson, J

Brunström, B

Halldin, K

Stigson, M

Dencker, L

机构：

[1] Uppsala Univ, Ctr Biomed, Dept Pharmaceut Biosci, Div Toxicol, SE-75124 Uppsala, Sweden

[2] Uppsala Univ, Ctr Reprod Biol Uppsala, SE-75124 Uppsala, Sweden

[3] Uppsala Univ, Dept Environm Toxicol, SE-75236 Uppsala, Sweden

[4] Karolinska Inst, Inst Environm Med, SE-17177 Stockholm, Sweden

来源：

BMC NEUROSCIENCE | 2006年 / 7卷 / 1期

关键词：

D O I：

10.1186/1471-2202-7-12

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: Differentiation of the brain during development leads to sexually dimorphic adult reproductive behavior and other neural sex dimorphisms. Genetic mechanisms independent of steroid hormones produced by the gonads have recently been suggested to partly explain these dimorphisms. Results: Using cDNA microarrays and real-time PCR we found gene expression differences between the male and female embryonic brain (or whole head) that may be independent of morphological differentiation of the gonads. Genes located on the sex chromosomes (ZZ in males and ZW in females) were common among the differentially expressed genes, several of which (WPKCI-8, HINT, MHM non-coding RNA) have previously been implicated in avian sex determination. A majority of the identified genes were more highly expressed in males. Three of these genes (CDK7, CCNH and BTF2-P44) encode subunits of the transcription factor IIH complex, indicating a role for this complex in neuronal differentiation. Conclusion: In conclusion, this study provides novel insights into sexually dimorphic gene expression in the embryonic chicken brain and its possible involvement in sex differentiation of the nervous system in birds.

引用

页数：17

共 77 条

[1] Neural, not gonadal, origin of brain sex differences in a gynandromorphic finch [J].

Agate, RJ ;

Grisham, W ;

Wade, J ;

Mann, S ;

Wingfield, J ;

Schanen, C ;

Palotie, A ;

Arnold, AP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (08) :4873-4878

[2] Sites of estrogen receptor and aromatase expression in the chicken embryo [J].

Andrews, JE ;

Smith, CA ;

Sinclair, AH .

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 1997, 108 (02) :182-190

[3]

Apweiler R, 2004, NUCLEIC ACIDS RES, V32, pD115, DOI [10.1093/nar/gkw1099, 10.1093/nar/gkh131]

[4] GONADAL-STEROID INDUCTION OF STRUCTURAL SEX-DIFFERENCES IN THE CENTRAL NERVOUS-SYSTEM [J].

ARNOLD, AP ;

GORSKI, RA .

ANNUAL REVIEW OF NEUROSCIENCE, 1984, 7 :413-442

[5] Sex chromosomes and brain gender [J].

Arnold, AP .

NATURE REVIEWS NEUROSCIENCE, 2004, 5 (09) :701-708

[6] The gender of the voice within: the neural origin of sex differences in the brain [J].

Arnold, AP .

CURRENT OPINION IN NEUROBIOLOGY, 2003, 13 (06) :759-764

[7] Do sex differences in the brain explain sex differences in the hormonal induction of reproductive behavior? What 25 years of research on the Japanese quail tells us [J].

Balthazart, J ;

Tlemcani, O ;

Ball, GF .

HORMONES AND BEHAVIOR, 1996, 30 (04) :627-661

[8]

Bateman A, 2004, NUCLEIC ACIDS RES, V32, pD138, DOI [10.1093/nar/gkp985, 10.1093/nar/gkr1065, 10.1093/nar/gkh121]

[9] CONTROLLING THE FALSE DISCOVERY RATE - A PRACTICAL AND POWERFUL APPROACH TO MULTIPLE TESTING [J].

BENJAMINI, Y ;

HOCHBERG, Y .

JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 1995, 57 (01) :289-300

[10]

Benson Dennis A, 2005, Nucleic Acids Res, V33, pD34

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