CaMKII and Its Role in Cardiac Arrhythmia

被引：42

作者：

Erickson, J. R. ^{[1
]}

Anderson, M. E. ^{[1
,2
]}

机构：

[1] Univ Iowa, Carver Coll Med, Dept Internal Med, Iowa City, IA 52242 USA

[2] Univ Iowa, Carver Coll Med, Dept Mol Physiol & Biophys, Iowa City, IA 52242 USA

来源：

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY | 2008年 / 19卷 / 12期

关键词：

CaMKII; arrhythmia; hypertrophy; oxidation;

D O I：

10.1111/j.1540-8167.2008.01295.x

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

CaMKII and Its Role in Cardiac Arrhythmia. Calcium/calmodulin-dependent kinase II (CaMKII) is a multifunctional serine/threonine kinase widely distributed in a number of tissue types. Activation of CaMKII has been linked to important downstream physiological processes, including apoptosis, hypertrophy, and arrhythmia in the heart. Pharmacological or genetic inhibition of CaMKII has been shown to improve health outcomes in a number of animal models. In this review, we summarize the structural and functional properties of CaMKII and detail its role in cardiac arrhythmia, structural heart disease, and sudden death. (J Cardiovasc Electrophysiol, Vol. 19, pp. 1332-1336, December 2008).

引用

页码：1332 / 1336

页数：5

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