Inhibition of carbonic anhydrase isozymes I and II with natural products extracted from plants, mushrooms and honey

被引：40

作者：

Sahin, Huseyin ^{[1
]}

Can, Zehra ^{[1
]}

Yildiz, Oktay ^{[1
]}

Kolayli, Sevgi ^{[1
]}

Innocenti, Alessio ^{[2
]}

Scozzafava, Gabriele ^{[3
]}

Supuran, Claudiu T. ^{[2
]}

机构：

[1] Karadeniz Tech Univ, Dept Chem, TR-61080 Trabzon, Turkey

[2] Univ Florence, Lab Chim Bioinorgan, Florence, Italy

[3] Univ Florence, Dipartimento Econ Ingn Sci & Tecnol Agr Forestali, Florence, Italy

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2012年 / 27卷 / 03期

关键词：

Carbonic anhydrase; natural products; phenol; inhibition; isoform I and II; ACTIVE-SITE; CRYSTAL-STRUCTURE; SULFONAMIDES; ANTIOXIDANT; CHEMOTYPES; COUMARINS; CAPACITY; BINDING; ENZYME;

D O I：

10.3109/14756366.2011.593176

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Different natural products and secondary metabolites from mushrooms, teas, honeys, mosses, plants and seaweeds were investigated for their in vitro inhibitory effects on human carbonic anhydrase (hCA, E.C.4.2.1.1) isoforms I and II. Inhibition data were correlated with the total phenol content in the extract and investigated with the pure compounds believed to be responsible for this activity. Methanolic extracts were prepared for 17 such pure chemicals present in the natural products and for 41 diverse natural products. The IC50 values were in the range of 0.11-66.50 mu g/mL against hCA I and of 0.09-54.54 mu g/mL against hCA II, respectively. The total phenol content was in the range of 0.02-1318.96 (as milligrams of gallic acid equivalents) per gram of sample. These data offer new insights on possible novel classes of CA inhibitors based on natural products, possessing a range of chemical structures not present in the classical inhibitors with pharmacological applications, such as the sulfonamides and sulfamates.

引用

页码：395 / 402

页数：8

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