Cell signalling - Calmodulin at the channel gate

被引：27

作者：

Ehlers, MD ^{[1
]}

Augustine, GJ ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Neurobiol, Durham, NC 27710 USA

来源：

NATURE | 1999年 / 399卷 / 6732期

关键词：

D O I：

10.1038/20079

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

When calcium enters the cell it regulates a host of intracellular signalling processes, including activity of the channels that transported it in there. These voltage-gated Ca2+ channels can be either inactivated or stimulated by Ca2+, and it now turns out that both of these functions are modulated by the same molecule — the classical Ca2+receptor protein calmodulin.

引用

页码：105 / +

页数：3

共 15 条

[11] Calmodulin is the Ca2+ sensor for Ca2+-dependent inactivation of 1-type calcium channels [J].

Peterson, BZ ;

DeMaria, CD ;

Yue, DT .

NEURON, 1999, 22 (03) :549-558

[12] Ca2+-induced inhibition of the cardiac Ca2+ channel depends on calmodulin [J].

Qin, N ;

Olcese, R ;

Bransby, M ;

Lin, T ;

Birnbaumer, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (05) :2435-2438

[13] Mechanism of calcium gating in small-conductance calcium-activated potassium channels [J].

Xia, XM ;

Fakler, B ;

Rivard, A ;

Wayman, G ;

Johnson-Pais, T ;

Keen, JE ;

Ishii, T ;

Hirschberg, B ;

Bond, CT ;

Lutsenko, S ;

Maylie, J ;

Adelman, JP .

NATURE, 1998, 395 (6701) :503-507

[14] Ca2+-sensitive inactivation of L-type Ca2+ channels depends on multiple cytoplasmic amino acid sequences of the α1C subunit [J].

Zühlke, RD ;

Reuter, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (06) :3287-3294

[15] Calmodulin supports both inactivation and facilitation of L-type calcium channels [J].

Zühlke, RD ;

Pitt, GS ;

Deisseroth, K ;

Tsien, RW ;

Reuter, H .

NATURE, 1999, 399 (6732) :159-162

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