Citrinin revisited: from monomers to dimers and beyond

被引：94

作者：

Clark, BR

Capon, RJ ^{[1
]}

Lacey, E

Tennant, S

Gill, JH

机构：

[1] Univ Queensland, Inst Mol Biosci, Ctr Mol Biodivers, Brisbane, Qld 4072, Australia

[2] Microbial Screening Technol Pty Ltd, Smithfield, NSW 2164, Australia

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2006年 / 4卷 / 08期

关键词：

D O I：

10.1039/b600960c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Detailed chemical analysis of the solid phase fermentation of an Australian Penicillium citrinum isolate has returned the known compounds citrinin (1), phenol A acid (6), dihydrocitrinone (7) and dihydrocitrinin (8), together with a novel cytotoxic dimer, dicitrinin A (5). Dicitrinin A (5) was determined to be a dimerised artefact of the major co-metabolite citrinin, and its structure solved by spectroscopic analysis and chemical modi. cation. Analysis of the products encountered during the controlled decomposition of citrinin led to the discovery of additional citrinin dimers and delineated a plausible mechanistic pathway linking all monomeric and dimeric citrinin degradation products.

引用

页码：1520 / 1528

页数：9

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