2,3,4-trimethyl-5,7-dihydroxy-2,3-dihydrobenzofuran, a novel antioxidant, from Penicillium citrinum F5

被引：79

作者：

Chen, CH

Shaw, CY

Chen, CC

Tsai, YC

机构：

[1] Natl Yang Ming Univ, Inst Biochem, Taipei 112, Taiwan

[2] Natl Res Inst Chinese Med, Taipei 112, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 05期

关键词：

D O I：

10.1021/np010605o

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioassy-directed fractionation of a culture broth of Penicillium citrinum F5 led to the isolation of a novel antioxidant 2,3,4-trimethyl-5,7-dihydroxy-2,3-dihydrobenzofuran (1), together with gentisic acid (2), and their structures were determined on the basis of spectroscopic data. In the 1,1-diphonyl-pieryl-hydrazyl (DPPH) assay system, compounds 1 and 2 showed free radical scavenging activity with IC20 values of 10.39 and 4.26 muM, respectively.

引用

收藏

页码：740 / 741

页数：2

相关论文

共 8 条

[1] AGING, ENERGY, AND OXIDATIVE STRESS IN NEURODEGENERATIVE DISEASES [J].

BEAL, MF .

ANNALS OF NEUROLOGY, 1995, 38 (03) :357-366

[2] Vasorelaxing and antioxidant constituents from Hernandia nymphaeifolia [J].

Chen, JJ ;

Chang, YL ;

Teng, CM ;

Chen, IS .

PLANTA MEDICA, 2001, 67 (07) :593-598

[3] The oxidative modification hypothesis of atherogenesis: An overview [J].

Chisolm, GM ;

Steinberg, D .

FREE RADICAL BIOLOGY AND MEDICINE, 2000, 28 (12) :1815-1826

[4] SYNTHETIC APPLICATIONS OF INTRA-MOLECULAR INSERTION IN ARYLCARBENES .4. ORTHO-ALKOXY-1-PHENYLETHYLIDENES, DIALKYLAMINO-1-PHENYLETHYLIDENES AND ALKYLTHIO-1-PHENYLETHYLIDENES [J].

CROW, WD ;

MCNAB, H .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1979, 32 (01) :123-131

[5] TANNINS AND RELATED-COMPOUNDS .54. PHENOLIC GLUCOSIDE GALLATES FROM QUERCUS-MONGOLICA AND QUERCUS-ACUTISSIMA [J].

ISHIMARU, K ;

NONAKA, G ;

NISHIOKA, I .

PHYTOCHEMISTRY, 1987, 26 (04) :1147-1152

[6] FREE-RADICALS AS MEDIATORS OF TISSUE-INJURY AND DISEASE [J].

KEHRER, JP .

CRITICAL REVIEWS IN TOXICOLOGY, 1993, 23 (01) :21-48

[7]

KO FN, 1995, BBA-LIPID LIPID MET, V1258, P145

[8] OXYGEN RADICAL PRODUCTION DURING ISCHEMIA - REPERFUSION IN THE ISOLATED PERFUSED-RAT-LIVER AS MONITORED BY LUMINOL ENHANCED CHEMILUMINESCENCE [J].

OKUDA, M ;

IKAI, I ;

CHANCE, B ;

KUMAR, C .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 174 (01) :217-221