Effects of chronic ingestion of catechin-rich green tea on hepatic gene expression of gluconeogenic enzymes in rats

被引：22

作者：

Abe, Koichi ^{[1
,2
,4
]}

Okada, Norihisa ^{[1
,2
]}

Tanabe, Hiroki ^{[1
,2
]}

Fukutomi, Ryuuta ^{[3
]}

Yasui, Kensuke ^{[5
]}

Isemura, Mamoru ^{[1
,2
]}

Kinae, Naohide ^{[1
,2
]}

机构：

[1] Univ Shizuoka, Grad Sch Nutr & Environm Sci, Shizuoka 4228526, Japan

[2] Univ Shizuoka, Global COE, Shizuoka 4228526, Japan

[3] Nisshin Seifun Grp Inc, Fujimino, Saitama, Japan

[4] Kumiai Chem Ind Co Ltd, Shizuoka 4390031, Japan

[5] Nisshin Pharma Inc, Fujimino, Saitama, Japan

来源：

BIOMEDICAL RESEARCH-TOKYO | 2009年 / 30卷 / 01期

关键词：

GLUCOSE-6-PHOSPHATASE GENE; EPIGALLOCATECHIN GALLATE; GLUCOSE-PRODUCTION; IN-VIVO; LIVER; TRANSCRIPTION; METABOLISM; INSULIN; ALPHA; CELLS;

D O I：

10.2220/biomedres.30.25

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Normal rats were given catechin-rich green tea as drinking fluid and the effects on hepatic gene expression were examined. The results of DNA microarray analysis and quantitative real-time reverse transcription-polymerase chain reaction indicated the down-regulated expression of genes for glucose-6-phosphatase (G6Pase) and fatty acid synthase, and the up-regulated expression of peroxisome proliferator activated receptor cc in the rats given green tea for 4 weeks as compared with the water-given animals. One may expect anti-diabetic activity by catechin-rich green tea through its chronic down-regulatory effect on G6Pase expression.

引用

页码：25 / 29

页数：5

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