Serious drug-induced liver disease secondary to ezetimibe

被引：16

作者：

Castellote, Jose ^{[1
]}

Ariza, Javier ^{[1
]}

Rota, Rosa ^{[1
]}

Girbau, Anna ^{[1
]}

Xiol, Xavier ^{[1
]}

机构：

[1] Hosp Univ Bellvitge, Hepatol & Liver Transplant Unit, Barcelona 08907, Spain

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2008年 / 14卷 / 32期

关键词：

ezetimibe; hepatitis; drug-induced liver disease;

D O I：

10.3748/wjg.14.5098

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Ezetimibe is the first member of a new family of lipid-lowering drugs that inhibits uptake of dietary and biliary cholesterol. It was approved by the FDA in 2002 for hypercholesterolemia alone or in combination with statins. Its use has been spreading over the last years. Ezetimibe was considered a safe drug. We report a case of a woman who developed a serious hepatocellular drug-induced liver disease after 4 mo therapy with 10 mg daily of ezetimibe. After withdrawal of the drug, the patient recovered slowly. Ezetimibe may produce serious toxic hepatitis and prompt withdrawal is mandatory in case of a significant abnormality in liver testing after beginning or during treatment with ezetimibe. (C) 2008 The WIG Press. All rights reserved.

引用

页码：5098 / 5099

页数：2

共 9 条

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