Synthesis and anti-inflammatory activity of natural and semisynthetic geranyloxycoumarins

被引：58

作者：

Curini, M

Epifano, F

Maltese, F

Marcotullio, MC

Tubaro, A

Altinier, G

Gonzales, SP

Rodriguez, JC

机构：

[1] Univ Perugia, Sez Chim Organ, Dipartimento Chim & Tecnol Farmaco, I-06123 Perugia, Italy

[2] Univ Trieste, DEMREP, I-34127 Trieste, Italy

[3] CQF, Dept Sintesis Quim, Havana 11600, Cuba

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 09期

关键词：

geranyloxycoumarins; collinin; auraptene; anti-inflammatory activity;

D O I：

10.1016/j.bmcl.2004.02.009

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Nine new 7-geranyloxycoumarin derivatives differently substituted at position 8 were semi-synthesised. Their topical anti-inflammatory activity was evaluated using the Croton oil ear test in mice as a model of acute inflammation. Auraptene (7-geranytoxycoumarin), its 8-methoxy (collinin, 1) and 8-acetoxy derivatives (5) (1 mumol/cm(1)) provoked 50% oedema reduction, similarly to 0.25 mumol/cm(2) of the reference drug indomethacin, a nonsteroidal anti-inflammatory drug. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：2241 / 2243

页数：3

共 12 条

[1] THE CHEMICAL CONSTITUENTS OF AUSTRALIAN FLINDERSIA SPECIES .5. THE CONSTITUENTS OF FLINDERSIA-MACULOSA LINDL [J].