Circulating mesenchymal stem cells

被引：208

作者：

Roufosse, CA

Direkze, NC

Otto, WR

Wright, NA

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Histopathol, London W12 0NN, England

[2] Canc Res UK, Histopathol Unit, London WC2A 3PX, England

[3] Barts & London Hosp, Queen Marys Sch Med & Dent, Dept Histopathol, London E1 2AD, England

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2004年 / 36卷 / 04期

基金：

英国惠康基金;

关键词：

mesenchymal stem cell; mesenchymal precursor cell; circulating stem cell; peripheral blood precursor cell; peripheral blood stem cell;

D O I：

10.1016/j.biocel.2003.10.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mesenchymal precursor cells (MPCs) are multipotent cells capable of differentiating into various mesenchymal tissues, such as bone, cartilage, fat, tendon and muscle. They are present within both mesenchymal tissues and the bone marrow (BM). If marrow-derived MPCs are to have a role in repair and fibrosis of mesenchymal tissues, transit of these cells through the peripheral blood is to be expected. Although there is evidence for the existence of MPCs within the peripheral blood, results are debated and are not always reproducible. Variations in the methods of cell purification, culture and characterisation may explain the inconsistent results obtained in different studies. (C) 2003 Elsevier Ltd. All rights reserved.

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页码：585 / 597

页数：13

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