SIRT3 regulation of mitochondrial oxidative stress

被引：275

作者：

Bause, Alexandra S. ^{[1
]}

Haigis, Marcia C. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

来源：

EXPERIMENTAL GERONTOLOGY | 2013年 / 48卷 / 07期

关键词：

SIRT3; Mitochondria; Reactive oxygen species; Metabolism; Aging; COACTIVATOR 1-ALPHA PGC-1-ALPHA; OXYGEN SPECIES PRODUCTION; FATTY-ACID OXIDATION; CALORIE RESTRICTION; LYSINE ACETYLATION; SIRT3-MEDIATED DEACETYLATION; TRANSCRIPTIONAL COACTIVATOR; SUPEROXIDE-PRODUCTION; METABOLIC REGULATOR; THIOREDOXIN SYSTEM;

D O I：

10.1016/j.exger.2012.08.007

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Mitochondria play a central role in the production of reactive oxygen species as byproducts of metabolism and energy production. In order to protect cellular structures from oxidative stress-induced damage, cells have evolved elegant mechanisms for mitochondrial ROS detoxification. The mitochondrial sirtuin, SIRT3, is emerging as a pivotal regulator of oxidative stress by deacetylation of substrates involved in both ROS production and detoxification. This review will summarize recent findings on the regulation of mitochondrial ROS homeostasis by SIRT3. (C) 2012 Published by Elsevier Inc.

引用

页码：634 / 639

页数：6

共 56 条

[1] A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis [J].

Ahn, Bong-Hyun ;

Kim, Hyun-Seok ;

Song, Shiwei ;

Lee, In Hye ;

Liu, Jie ;

Vassilopoulos, Athanassios ;

Deng, Chu-Xia ;

Finkel, Toren .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (38) :14447-14452

[2] Peroxisome Proliferator-activated Receptor γ Co-activator 1α (PGC-1α) and Sirtuin 1 (SIRT1) Reside in Mitochondria POSSIBLE DIRECT FUNCTION IN MITOCHONDRIAL BIOGENESIS [J].

Aquilano, Katia ;

Vigilanza, Paola ;

Baldelli, Sara ;

Pagliei, Beatrice ;

Rotilio, Giuseppe ;

Ciriolo, Maria Rosa .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (28) :21590-21599

[3] Mitochondria, oxidants, and aging [J].

Balaban, RS ;

Nemoto, S ;

Finkel, T .

CELL, 2005, 120 (04) :483-495

[4] SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production [J].

Bell, E. L. ;

Emerling, B. M. ;

Ricoult, S. J. H. ;

Guarente, L. .

ONCOGENE, 2011, 30 (26) :2986-2996

[5] The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production [J].

Bell, Eric L. ;

Klimova, Tatyana A. ;

Eisenbart, James ;

Moraes, Carlos T. ;

Murphy, Michael P. ;

Budinger, G. R. Scott ;

Chandel, Navdeep S. .

JOURNAL OF CELL BIOLOGY, 2007, 177 (06) :1029-1036

[6] The sites and topology of mitochondrial superoxide production [J].

Brand, Martin D. .

EXPERIMENTAL GERONTOLOGY, 2010, 45 (7-8) :466-472

[7] Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase [J].

Brunet, A ;

Sweeney, LB ;

Sturgill, JF ;

Chua, KF ;

Greer, PL ;

Lin, YX ;

Tran, H ;

Ross, SE ;

Mostoslavsky, R ;

Cohen, HY ;

Hu, LS ;

Cheng, HL ;

Jedrychowski, MP ;

Gygi, SP ;

Sinclair, DA ;

Alt, FW ;

Greenberg, ME .

SCIENCE, 2004, 303 (5666) :2011-2015

[8] Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS [J].

Chen, Yaohui ;

Zhang, Jinye ;

Lin, Yan ;

Lei, Qunying ;

Guan, Kun-Liang ;

Zhao, Shimin ;

Xiong, Yue .

EMBO REPORTS, 2011, 12 (06) :534-541

[9] Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions [J].

Choudhary, Chunaram ;

Kumar, Chanchal ;

Gnad, Florian ;

Nielsen, Michael L. ;

Rehman, Michael ;

Walther, Tobias C. ;

Olsen, Jesper V. ;

Mann, Matthias .

SCIENCE, 2009, 325 (5942) :834-840

[10] Regulation of Succinate Dehydrogenase Activity by SIRT3 in Mammalian Mitochondria [J].

Cimen, Huseyin ;

Han, Min-Joon ;

Yang, Yongjie ;

Tong, Qiang ;

Koc, Hasan ;

Koc, Emine C. .

BIOCHEMISTRY, 2010, 49 (02) :304-311

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