Serpin B3/B4, activated by STAT3, promote survival of squamous carcinoma cells

被引：19

作者：

Ahmed, Simi T. ^{[1
]}

Darnell, James E., Jr. ^{[1
]}

机构：

[1] Rockefeller Univ, Mol Cell Biol Lab, New York, NY 10065 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2009年 / 378卷 / 04期

关键词：

STAT3; Serpin B3/B4 squamous cancer; PROSTATE-CANCER CELLS; CONSTITUTIVE ACTIVATION; EXPRESSION; GENE; INHIBITOR; ANTIGEN; HEAD; TRANSCRIPTION; APOPTOSIS; CYTOKINES;

D O I：

10.1016/j.bbrc.2008.11.147

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Persistently activated STAT3 contributes to cell survival in many different human cancers. Cancer cell secretion of IL-6 is a frequent basis for persistent STAT3 activation; we show that antibodies against signaling unit of the IL-6 receptor, can abruptly remove persistently activated causing prompt disappearance of cysteine proteases of serpin B3/B4 mRNAs, known as squamous cell carcinoma antigens 1 and 2. STAT3 occupies the promoter of serpin B3/B4 before removal and siRNA removal of B3/B4 mRNA caused cell death in HN13 head and neck cancer cells. Thus persistently activated STAT3 is a required part of the continuous activation of B3/B4 genes, which protects tumor cells from (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：821 / 825

页数：5

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