Glutathione depletion in the brain disrupts short-term spatial memory in the Y-maze in rats and mice

被引：64

作者：

Dean, Olivia ^{[1
,2
]}

Bush, Ashley I. ^{[1
]}

Berk, Michael ^{[2
,3
]}

Copolov, David L. ^{[4
]}

van den Buuse, Maarten ^{[1
]}

机构：

[1] Mental Hlth Res Inst, Parkville, Vic 3052, Australia

[2] Univ Melbourne, Dept Clin & Biomed Sci, Swanston Ctr, Geelong, Vic 3220, Australia

[3] ORYGEN Res Ctr, Parkville, Vic 3052, Australia

[4] Monash Univ, Clayton, Vic 3800, Australia

来源：

BEHAVIOURAL BRAIN RESEARCH | 2009年 / 198卷 / 01期

基金：

英国医学研究理事会;

关键词：

Schizophrenia; Bipolar disorder; Glutathione; Oxidative stress; Animal model; 2-Cyclohexene-1-one; Y-maze; Cognition; DOPAMINE UPTAKE INHIBITION; L-BUTHIONINE SULFOXIMINE; OXIDATIVE STRESS; ANIMAL-MODEL; COGNITIVE IMPAIRMENT; CEREBRAL GLUTATHIONE; ANTIOXIDANT DEFENSE; CEREBROSPINAL-FLUID; SCHIZOPHRENIA; RELEVANCE;

D O I：

10.1016/j.bbr.2008.11.017

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

010107 [宗教学]; 030301 [社会学]; 070906 [古生物学及地层学（含古人类学）];

摘要：

Oxidative stress and reduced brain glutathione (GSH) levels have been reported in psychiatric illnesses including schizophrenia and bipolar disorder. However the role of GSH in cognitive impairment in the illness remains unclear. Treatment of Sprague-Dawley rats and C57Bl/6 mice with 2-cyclohexene-1-one (CHX) dose-dependently reduced striatal and frontal cortical GSH levels similar to those in schizophrenia. In both species, GSH depletion resulted in disruption of short-term spatial recognition memory in a Y-maze test. In conclusion, GSH depletion induces cognitive impairment, which may be relevant to the role of GSH in psychiatric illnesses. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：258 / 262

页数：5

共 42 条

[1]

Serotonin depletion in the dorsal and ventral hippocampus: Effects on locomotor hyperactivity, prepulse inhibition and learning and memory [J].

Adams, Wendy ;

Kusljic, Snezana ;

van den Buuse, Maarten .

NEUROPHARMACOLOGY, 2008, 55 (06) :1048-1055

[2]

Potential role of cerebral glutathione in the maintenance of blood-brain barrier integrity in rat [J].

Agarwal, R ;

Shukla, GS .

NEUROCHEMICAL RESEARCH, 1999, 24 (12) :1507-1514

[3]

ALTSCHULE MD, 1960, COMPR PSYCHIAT, V1, P250

[4]

Oxidative stress markers in bipolar disorder: A meta-analysis [J].

Andreazza, Ana C. ;

Kauer-Sant'Anna, Marcia ;

Frey, Benicio N. ;

Bond, David J. ;

Kapczinski, Flavio ;

Young, L. Trevor ;

Yatham, Lakshmi N. .

JOURNAL OF AFFECTIVE DISORDERS, 2008, 111 (2-3) :135-144

[5]

MICROTITER PLATE ASSAY FOR THE MEASUREMENT OF GLUTATHIONE AND GLUTATHIONE DISULFIDE IN LARGE NUMBERS OF BIOLOGICAL SAMPLES [J].

BAKER, MA ;

CERNIGLIA, GJ ;

ZAMAN, A .

ANALYTICAL BIOCHEMISTRY, 1990, 190 (02) :360-365

[6]

BENZI, G ;

CURTI, D ;

MARZATICO, F ;

PASTORIS, O .

JOURNAL OF NEUROSCIENCE RESEARCH, 1991, 29 (04) :527-532

[7]

N-acetyl cysteine for depressive symptoms in bipolar disorder - A double-blind randomized placebo-controlled trial [J].

Berk, Michael ;

Copolov, David L. ;

Dean, Olivia ;

Lu, Kristy ;

Jeavons, Sue ;

Schapkaitz, Ian ;

Anderson-Hunt, Murray ;

Bush, Ashley I. .

BIOLOGICAL PSYCHIATRY, 2008, 64 (06) :468-475

[8]

N-acetyl cysteine as a glutathione precursor for schizophrenia - A double-blind, randomized, placebo-controlled trial [J].

Berk, Michael ;

Copolov, David ;

Dean, Olivia ;

Lu, Kristy ;

Jeavons, Sue ;

Schapkaitz, Ian ;

Anderson-Hunt, Murray ;

Judd, Fiona ;

Katz, Fiona ;

Katz, Paul ;

Ording-Jespersen, Sean ;

Little, John ;

Conus, Philippe ;

Cuenod, Michel ;

Do, Kim Q. ;

Bush, Ashley I. .

BIOLOGICAL PSYCHIATRY, 2008, 64 (05) :361-368

[9]

Transitory glutathione deficit during brain development induces cognitive impairment in juvenile and adult rats:: Relevance to schizophrenia [J].

Cabungcal, Jan-Harry ;

Preissmann, Delphine ;

Delseth, Caroline ;

Cuenod, Michel ;

Do, Kim Q. ;

Schenk, Francoise .

NEUROBIOLOGY OF DISEASE, 2007, 26 (03) :634-645

[10]

An animal model with relevance to schizophrenia:: Sex-dependent cognitive deficits in osteogenic disorder-Shionogi rats induced by glutathione synthesis and dopamine uptake inhibition during development [J].

Castagné, V ;

Cuénod, M ;

Do, KQ .

NEUROSCIENCE, 2004, 123 (04) :821-834

← 1 2 3 4 5 →