Biology of Poly(ADP-Ribose) Polymerases: The Factotums of Cell Maintenance

被引：396

作者：

Bai, Peter ^{[1
,2
,3
]}

机构：

[1] Lendulet Cellular Metab Res Grp, H-4032 Debrecen, Hungary

[2] Univ Debrecen, Res Ctr Mol Med, H-4032 Debrecen, Hungary

[3] Univ Debrecen, Fac Med, Dept Med Chem, H-4032 Debrecen, Hungary

来源：

MOLECULAR CELL | 2015年 / 58卷 / 06期

关键词：

DNA-DAMAGE; MITOCHONDRIAL-FUNCTION; GLYCOHYDROLASE PARG; ADP-RIBOSYLATION; SKELETAL-MUSCLE; GENE-REGULATION; DEFICIENT MICE; PARP-1; ACTIVATION; RIBOSE;

D O I：

10.1016/j.molcel.2015.01.034

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The protein family of poly(ADP-ribose) polymerases (PARPs) or diphtheria toxin-type ADP-ribose transferases (ARTDs) are multidomain proteins originally identified as DNA repair factors. There are 17 PARP enzymes in humans, and it is now evident that PARPs undertake more tasks than DNA repair. The aim of this review is to give a comprehensive view of the biological roles of the PARP family starting from the simplest biochemical reactions to complex regulatory circuits. Special attention will be laid on discussing linkage of PARP enzymes with tumor biology, oxidative stress, inflammatory, and metabolic diseases. A better understanding of PARP-mediated processes and pathologies may help in identifying new pathways and, by these, new targets to combat diseases that affect large populations and seriously shorten life expectancy and the quality of life, such as cancer, metabolic, or inflammatory diseases.

引用

页码：947 / 958

页数：12

共 86 条

[1]

Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis [J].

Andrabi, Shaida A. ;

Umanah, George K. E. ;

Chang, Calvin ;

Stevens, Daniel A. ;

Karuppagounder, Senthilkumar S. ;

Gagne, Jean-Philippe ;

Poirier, Guy G. ;

Dawson, Valina L. ;

Dawson, Ted M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (28) :10209-10214

[2]

New drugs cost US$2.6 billion to develop [J].

不详 .

NATURE REVIEWS DRUG DISCOVERY, 2014, 13 (12) :877-877

[3]

Poly(ADP-Ribose) Polymerase 1 Participates in the Phase Entrainment of Circadian Clocks to Feeding [J].

Asher, Gad ;

Reinke, Hans ;

Altmeyer, Matthias ;

Gutierrez-Arcelus, Maria ;

Hottiger, Michael O. ;

Schibler, Ueli .

CELL, 2010, 142 (06) :943-953

[4]

Interferon-Stimulated Poly(ADP-Ribose) Polymerases Are Potent Inhibitors of Cellular Translation and Virus Replication [J].

Atasheva, Svetlana ;

Frolova, Elena I. ;

Frolov, Ilya .

JOURNAL OF VIROLOGY, 2014, 88 (04) :2116-2130

[5]

CORRELATION BETWEEN ENDOGENOUS NUCLEOSOMAL HYPER(ADP-RIBOSYL)ATION OF HISTONE-H1 AND THE INDUCTION OF CHROMATIN RELAXATION [J].

AUBIN, RJ ;

FRECHETTE, A ;

DEMURCIA, G ;

MANDEL, P ;

LORD, A ;

GRONDIN, G ;

POIRIER, GG .

EMBO JOURNAL, 1983, 2 (10) :1685-1693

[6]

Poly(ADP-ribose) polymerases as modulators of mitochondrial activity [J].

Bai, Peter ;

Nagy, Lille ;

Fodor, Tamas ;

Liaudet, Lucas ;

Pacher, Pal .

TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2015, 26 (02) :75-83

[7]

The Role of PARP-1 and PARP-2 Enzymes in Metabolic Regulation and Disease [J].

Bai, Peter ;

Canto, Carles .

CELL METABOLISM, 2012, 16 (03) :290-295

[8]

The Promise of Proteomics for the Study of ADP-Ribosylation [J].

Bock, Florian J. ;

Todorova, Tanya T. ;

Chang, Paul .

MOLECULAR CELL, 2015, 58 (06) :911-924

[9]

RNA Regulation by Poly(ADP-Ribose) Polymerases [J].

Bock, Florian J. ;

Todorova, Tanya T. ;

Chang, Paul .

MOLECULAR CELL, 2015, 58 (06) :959-969

[10]

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase [J].

Bryant, HE ;

Schultz, N ;

Thomas, HD ;

Parker, KM ;

Flower, D ;

Lopez, E ;

Kyle, S ;

Meuth, M ;

Curtin, NJ ;

Helleday, T .

NATURE, 2005, 434 (7035) :913-917

← 1 2 3 4 5 6 7 8 9 →