Roles of NHERF1/EBP50 in cancer

被引：87

作者：

Georgescu, Maria-Magdalena ^{[1
]}

Morales, Fabiana C. ^{[1
]}

Molina, Jennifer R. ^{[1
]}

Hayashi, Yuho ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Neurooncol, Houston, TX 77030 USA

来源：

CURRENT MOLECULAR MEDICINE | 2008年 / 8卷 / 06期

关键词：

D O I：

10.2174/156652408785748031

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

This review summarizes the emerging roles of NHERF1/EBP50 adaptor protein in tumorigenesis. NHERF1/EBP50 ((N) under bara(+)/(H) under bar (+) (e) under bar xchanger (r) under bar egulating (f) under bar actor 1; ezrin-radixin-moesin ((E) under bar RM) (b) under bar inding (p) under bar hosphoprotein of 50 kDa) is a PDZ domain-containing protein with physiological localization at the plasma membrane. We discuss in this review the functions of NHERF1/EBP50 as a linker between membrane proteins and the cytoskeleton network, as well as its involvement in different types of cancer, such as breast and liver cancers. Recent evidence obtained from our laboratory and from other groups shows that NHERF1/EBP50 is an important player in cancer progression. It appears that, depending on its subcellular distribution, NHERF1/EBP50 may behave either as a tumor suppressor, when it is localized at the plasma membrane, or as an oncogenic protein, when it is shifted to the cytoplasm. We provide here an overview of the mechanisms by which this adaptor protein controls cell transformation, and propose a model suggesting a dual role of NHERF1/EBP50 in cancer.

引用

页码：459 / 468

页数：10

共 112 条

[1] High levels of ezrin expressed by human pancreatic adenocarcinoma cell lines with high metastatic potential [J].

Akisawa, N ;

Nishimori, I ;

Iwamura, T ;

Onishi, S ;

Hollingsworth, MA .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 258 (02) :395-400

[2] Type I phosphatidylinositol 4-phosphate 5-kinase controls neutrophil polarity and directional movement [J].

Ana Lacalle, Rosa ;

Peregil, Rosa M. ;

Pablo Albar, Juan ;

Merino, Ernesto ;

Martinez-A, Carlos ;

Merida, Isabel ;

Manes, Santos .

JOURNAL OF CELL BIOLOGY, 2007, 179 (07) :1539-1553

[3] Neurofibromatosis 2 [J].

Baser, ME ;

Evans, DGR ;

Gutmann, DH .

CURRENT OPINION IN NEUROLOGY, 2003, 16 (01) :27-33

[4] β-catenin:: A pivot between cell adhesion and Wnt signalling [J].

Bienz, M .

CURRENT BIOLOGY, 2005, 15 (02) :R64-R67

[5] Interaction between two adapter proteins, PAG and EBP50:: a possible link between membrane rafts and actin cytoskeleton [J].

Brdicková, N ;

Brdicka, T ;

Andera, L ;

Spicka, J ;

Angelisová, P ;

Milgram, SL ;

Horejsí, V .

FEBS LETTERS, 2001, 507 (02) :133-136

[6] ERM-merlin and EBP50 protein families in plasma membrane organization and function [J].

Bretscher, A ;

Chambers, D ;

Nguyen, R ;

Reczek, D .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2000, 16 :113-+

[7] Cystic fibrosis transmembrane conductance regulator activation is reduced in the small intestine of Na+/H+ exchanger 3 regulatory factor 1 (NHERF-1)-but not NHERF-2-deficient mice [J].

Broere, Nellie ;

Hillesheim, Jutta ;

Tuo, Biguang ;

Jorna, Huub ;

Houtsmuller, Adriaan B. ;

Shenolikar, Shirish ;

Weinman, Edward J. ;

Donowitz, Mark ;

Seidler, Ursula ;

de Jonge, Hugo R. ;

Hogema, Boris M. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (52) :37575-37584

[8] A kinase-regulated PDZ-domain interaction controls endocytic sorting of the β2-adrenergic receptor [J].

Cao, TT ;

Deacon, HW ;

Reczek, D ;

Bretscher, A ;

von Zastrow, M .

NATURE, 1999, 401 (6750) :286-290

[9] The NHERF1 PDZ2 domain regulates PKA-RhoA-p38-mediated NHE1 activation and invasion in breast tumor cells [J].

Cardone, Rosa A. ;

Bellizzi, Antonia ;

Busco, Giovanni ;

Weinman, Edward J. ;

Dell'Aquila, Maria E. ;

Casavola, Valeria ;

Azzariti, Amalia ;

Mangia, Anita ;

Paradiso, Angelo ;

Reshkin, Stephan J. .

MOLECULAR BIOLOGY OF THE CELL, 2007, 18 (05) :1768-1780

[10] The nuclear receptor hepatocyte nuclear factor 4α acts as a morphogen to induce the formation of microvilli [J].

Chiba, Hideki ;

Sakai, Naoyuki ;

Murata, Masaki ;

Osanai, Makoto ;

Ninomiya, Takafumi ;

Kojima, Takashi ;

Sawada, Norimasa .

JOURNAL OF CELL BIOLOGY, 2006, 175 (06) :971-980

← 1 2 3 4 5 6 7 8 9 10 →