Roles of NHERF1/EBP50 in cancer

被引：87

作者：

Georgescu, Maria-Magdalena ^{[1
]}

Morales, Fabiana C. ^{[1
]}

Molina, Jennifer R. ^{[1
]}

Hayashi, Yuho ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Neurooncol, Houston, TX 77030 USA

来源：

CURRENT MOLECULAR MEDICINE | 2008年 / 8卷 / 06期

关键词：

D O I：

10.2174/156652408785748031

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

This review summarizes the emerging roles of NHERF1/EBP50 adaptor protein in tumorigenesis. NHERF1/EBP50 ((N) under bara(+)/(H) under bar (+) (e) under bar xchanger (r) under bar egulating (f) under bar actor 1; ezrin-radixin-moesin ((E) under bar RM) (b) under bar inding (p) under bar hosphoprotein of 50 kDa) is a PDZ domain-containing protein with physiological localization at the plasma membrane. We discuss in this review the functions of NHERF1/EBP50 as a linker between membrane proteins and the cytoskeleton network, as well as its involvement in different types of cancer, such as breast and liver cancers. Recent evidence obtained from our laboratory and from other groups shows that NHERF1/EBP50 is an important player in cancer progression. It appears that, depending on its subcellular distribution, NHERF1/EBP50 may behave either as a tumor suppressor, when it is localized at the plasma membrane, or as an oncogenic protein, when it is shifted to the cytoplasm. We provide here an overview of the mechanisms by which this adaptor protein controls cell transformation, and propose a model suggesting a dual role of NHERF1/EBP50 in cancer.

引用

页码：459 / 468

页数：10

共 112 条

[11] THE RAT-BRAIN POSTSYNAPTIC DENSITY FRACTION CONTAINS A HOMOLOG OF THE DROSOPHILA DISKS-LARGE TUMOR SUPPRESSOR PROTEIN [J].

CHO, KO ;

HUNT, CA ;

KENNEDY, MB .

NEURON, 1992, 9 (05) :929-942

[12] The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells [J].

Coopman, PJP ;

Do, MTH ;

Barth, M ;

Bowden, ET ;

Hayes, AJ ;

Basyuk, E ;

Blancato, JK ;

Vezza, PR ;

McLeskey, SW ;

Mangeat, PH ;

Mueller, SC .

NATURE, 2000, 406 (6797) :742-747

[13]

CURTO M, 2007, BRIT J CANCER, V30, P30

[14] Contact-dependent inhibition of EGFR signaling by Nf2/Merlin [J].

Curto, Marcello ;

Cole, Banumathi K. ;

Lallemand, Dominique ;

Liu, Ching-Hui ;

McClatchey, Andrea I. .

JOURNAL OF CELL BIOLOGY, 2007, 177 (05) :893-903

[15] NHERF (Na+/H+ Exchanger Regulatory Factor) gene mutations in human breast cancer [J].

Dai, JL ;

Wang, L ;

Sahin, AA ;

Broemeling, LD ;

Schutte, M ;

Pan, Y .

ONCOGENE, 2004, 23 (53) :8681-8687

[16] Ligand-induced recruitment of Na+/H+-exchanger regulatory factor to the PDGF (platelet-derived growth factor) receptor regulates actin cytoskeleton reorganization by PDGF [J].

Demoulin, JB ;

Seo, JK ;

Ekman, S ;

Grapengiesser, E ;

Hellman, U ;

Rönnstrand, L ;

Heldin, CH .

BIOCHEMICAL JOURNAL, 2003, 376 :505-510

[17] NHERF family and NHE3 regulation [J].

Donowitz, M ;

Cha, BY ;

Zachos, NC ;

Brett, CL ;

Sharma, A ;

Tse, CM ;

Li, XH .

JOURNAL OF PHYSIOLOGY-LONDON, 2005, 567 (01) :3-11

[18] Estrogen receptor inducibility of the human Na+/H+ exchanger regulatory factor/ezrin-radixin-moesin binding protein 50 (NHE-RF/EBP50) gene involving multiple half-estrogen response elements [J].

Ediger, TR ;

Park, SE ;

Katzenellenbogen, BS .

MOLECULAR ENDOCRINOLOGY, 2002, 16 (08) :1828-1839

[19] Estrogen receptor regulation of the Na+/H+ exchanger regulatory factor [J].

Ediger, TR ;

Kraus, WL ;

Weinman, EJ ;

Katzenellenbogen, BS .

ENDOCRINOLOGY, 1999, 140 (07) :2976-2982

[20] Evidence for ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) self-association through PDZ-PDZ interactions [J].

Fouassier, L ;

Yun, CC ;

Fitz, JG ;

Doctor, RB .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (32) :25039-25045

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