Antioxidant and immunological activity in vitro of polysaccharides from Gomphidius rutilus mycelium

被引：147

作者：

Gao, Chanjuan ^{[1
,2
]}

Wang, Yanhua ^{[2
,3
]}

Wang, Chenyu ^{[1
]}

Wang, Zhanyong ^{[1
]}

机构：

[1] Liaoning Shihua Univ, Sch Environm & Biol Engn, Fushun 113001, Peoples R China

[2] Changan Univ, Sch Environm Sci & Engn, Xian 710064, Peoples R China

[3] CCCC First Highway Consultants Co Ltd, Environm Engn Subsidiary Court, Xian 710075, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2013年 / 92卷 / 02期

关键词：

Gomphidius Rutilus; Mycelium; Polysaccharide; Purification; Antioxidant; RESPONSE-SURFACE METHODOLOGY; ASSISTED EXTRACTION; OPTIMIZATION; ANTITUMOR;

D O I：

10.1016/j.carbpol.2012.12.011

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

Two novel polysaccharide fractions, GRMP1 and GRMP2, were isolated from the mycelium of Gomphidius rutilus through submerged fermentation. GRMP1 and GRMP2 had similar average molecular weights (35 and 31 kDa, respectively), and were composed of glucose and xylose at molar ratios of 0.46:1 and 0.63:1, respectively. In vitro antioxidant tests showed that GRMP1 and GRMP2 partly scavenged superoxide radical but almost had no scavenging effect on 1,1-diphenyl-2-picrylhydrazyl free radical. The effect of GRMP1 on hydroxyl radicals was stronger than that of GRMP2. Both GRMP1 and GRMP2 had relatively low reducing power and significant lymphocyte proliferation activity. In the presence of concanavalin A or lipopolysaccharide as mitogens for lymphocytes, the lymphocyte proliferation activity increased for GRMP1 but not for GRMP2 within the test dosage range. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：2187 / 2192

页数：6

共 27 条

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