Characterization and Bioavailability of Vitamin C Nanoliposomes Prepared by Film Evaporation-Dynamic High Pressure Microfluidization

被引：65

作者：

Yang, Shuibing ^{[1
]}

Liu, Wei ^{[1
]}

Liu, Chengmei ^{[1
]}

Liu, Weilin ^{[1
]}

Tong, Guihong ^{[1
]}

Zheng, Huijuan ^{[1
]}

Zhou, Wei ^{[1
]}

机构：

[1] Nanchang Univ, Dept Life Sci & Food Engn, State Key Lab Food Sci & Technol, Nanchang 330047, Peoples R China

来源：

JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY | 2012年 / 33卷 / 11期

基金：

中国国家自然科学基金;

关键词：

DPPH free radical scavenging assay; entrapment efficiency; skin permeation; stability; nanoliposomes; LIPOSOME FORMULATIONS; ASCORBIC-ACID; TOPICAL DELIVERY; SKIN PERMEATION; IN-VITRO; NANOPARTICLES; ENCAPSULATION; MULTILAMELLAR; PEROXIDATION; PENETRATION;

D O I：

10.1080/01932691.2011.629511

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

Vitamin C nanoliposomes were prepared by combining a conventional method (film evaporation) with dynamic high pressure microfluidization. Their physicochemical characterizations (antioxidant activity, particle size, entrapment efficiency, morphology, in vitro drug release, and storage stability) and skin permeation behavior were investigated. The results showed that vitamin C nanoliposomes, having equivalent DPPH (2, 2-diphenyl-1-picrylhydrazyl) free radical scavenging capacity of pure vitamin C solution without loss of their biological activity, exhibited better storage stability at 37 degrees C for 24 hours and at 4 degrees C for 60 days, a more excellent sustained drug release as well as higher skin penetration rate than vitamin C liposomes.

引用

页码：1608 / 1614

页数：7

共 39 条

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INTERACTION BETWEEN CORNEOCYTES AND STRATUM-CORNEUM LIPID LIPOSOMES INVITRO [J].