Recombinant bovine somatotropin decreases hepatic amino acid catabolism in female rats

被引：10

作者：

Blemings, KP

Gahl, MJ

Crenshaw, TD

Benevenga, NJ

机构：

[1] UNIV WISCONSIN, DEPT NUTR SCI, MADISON, WI 53706 USA

[2] UNIV WISCONSIN, DEPT MEAT & ANIM SCI, MADISON, WI 53706 USA

来源：

JOURNAL OF NUTRITION | 1996年 / 126卷 / 06期

关键词：

rats; somatotropin; lysine; methionine; valine;

D O I：

10.1093/jn/126.6.1657

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The effect of recombinant bovine somatotropin (rbST) on hepatic amino acid catabolism in female rats was investigated. Daily injections of rbST for 5 d decreased liver homogenate lysine alpha-ketoglutarate reductase (EC 1.5.1.8) activity (P < 0.05) and liver homogenate lysine oxidation (P < 0.05) similar to 35%. Liver homogenate methionine and valine oxidation were depressed similar to 20 (P = 0.13) and 35% (P < 0.05), respectively. These data show a decrease in hepatic capacity to oxidize amino acids in rats administered rbST. Whether depressed liver amino acid degrading enzyme activity plays a role in amino acid oxidation in vivo remains to be evaluated.

引用

页码：1657 / 1661

页数：5

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