Conformational disease

被引：762

作者：

Carrell, RW ^{[1
]}

Lomas, DA ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,ADDENBROOKES HOSP,MRC CTR,DEPT MED,CAMBRIDGE CB2 2QH,ENGLAND

来源：

LANCET | 1997年 / 350卷 / 9071期

关键词：

D O I：

10.1016/S0140-6736(97)02073-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Several diverse disorders, including the prevalent dementias and encephalopathies, are now believed to arise from the same general disease mechanism. In each, there is abnormal unfolding and then aggregation of an underlying protein. The gradual accumulation of these aggregates and the acceleration of their formation by stress explain the characteristic late or episodic onset of the clinical disease. The understanding of these processes at the molecular level is opening prospects of more rational approaches to investigation and therapy.

引用

页码：134 / 138

页数：5

共 40 条

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