Systems biology of antioxidants

被引：32

作者：

Andriantsitohaina, Ramaroson ^{[2
]}

Duluc, Lucie ^{[2
]}

Garcia-Rodriguez, Julio C. ^{[3
]}

Gil-Del Valle, Lizette ^{[4
]}

Guevara-Garcia, Mariela ^{[5
]}

Simard, Gilles ^{[2
]}

Soleti, Raffaella ^{[2
]}

Su, Ding-Feng ^{[6
]}

Velasquez-Perez, Luis ^{[7
]}

Wilson, John X. ^{[8
]}

Laher, Ismail ^{[1
]}

机构：

[1] Univ British Columbia, Fac Med, Dept Pharmacol & Therapeut, Vancouver, BC V6T 1Z4, Canada

[2] INSERM, U1063, F-49100 Angers, France

[3] Natl Ctr Anim Breeding CENPALAB, Havana, Cuba

[4] Inst Pedro Kouri, Havana, Cuba

[5] Biopharmaceut Labs LABIOFAM, Dept Res & Dev, Havana, Cuba

[6] Second Mil Med Univ, Dept Pharmacol, Shanghai 200433, Peoples R China

[7] Univ Havana, Ctr Res & Rehabil Hereditary Ataxias Carlos J Fin, Holguin 80100, Cuba

[8] SUNY Buffalo, Dept Exercise & Nutr Sci, Buffalo, NY 14214 USA

来源：

CLINICAL SCIENCE | 2012年 / 123卷 / 3-4期

基金：

美国国家卫生研究院;

关键词：

antioxidant; ataxia; diabetes; free radical; mitochondrion; sepsis; stroke; MITOCHONDRIAL SUPEROXIDE OVERPRODUCTION; OXYGEN SPECIES PRODUCTION; OXIDATIVE STRESS; NITRIC-OXIDE; COMPLEX-I; FREE-RADICALS; CARDIOVASCULAR-DISEASE; MOLECULAR-MECHANISMS; HIGH GLUCOSE; CELL-DEATH;

D O I：

10.1042/CS20110643

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Understanding the role of oxidative injury will allow for therapy with agents that scavenge ROS (reactive oxygen species) and antioxidants in the management of several diseases related to free radical damage. The majority of free radicals are generated by mitochondria as a consequence of the mitochondrial cycle, whereas free radical accumulation is limited by the action of a variety of antioxidant processes that reside in every cell. In the present review, we provide an overview of the mitochondrial generation of ROS and discuss the role of ROS in the regulation of endothelial and adipocyte function. Moreover, we also discuss recent findings on the role of ROS in sepsis, cerebral ataxia and stroke. These results provide avenues for the therapeutic potential of antioxidants in a variety of diseases.

引用

页码：173 / 192

页数：20

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