Effects of Physical Exercise on Autophagy and Apoptosis in Aged Brain: Human and Animal Studies

被引：44

作者：

Andreotti, Diana Zukas ^{[1
]}

Silva, Josiane do Nascimento ^{[1
]}

Matumoto, Amanda Midori ^{[1
]}

Orellana, Ana Maria ^{[2
]}

de Mello, Paloma Segura ^{[2
]}

Kawamoto, Elisa Mitiko ^{[1
]}

机构：

[1] Univ Sao Paulo, Lab Mol & Funct Neurobiol, Dept Pharmacol, Inst Biomed Sci, Sao Paulo, Brazil

[2] Univ Sao Paulo, Inst Biomed Sci, Lab Mol Neuropharmacol, Dept Pharmacol, Sao Paulo, Brazil

来源：

FRONTIERS IN NUTRITION | 2020年 / 7卷

基金：

巴西圣保罗研究基金会;

关键词：

aging; exercise; autophagy; apoptosis; brain; MODULATES CYTOKINE PROFILE; HEAVY RESISTANCE EXERCISE; ACUTE HORMONAL RESPONSES; DWELLING OLDER-ADULTS; HUMAN GROWTH-HORMONE; CEREBRAL-BLOOD-FLOW; AEROBIC EXERCISE; SLEEP QUALITY; TREADMILL EXERCISE; HIPPOCAMPAL NEUROGENESIS;

D O I：

10.3389/fnut.2020.00094

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 [营养与食品卫生学];

摘要：

The aging process is characterized by a series of molecular and cellular changes over the years that could culminate in the deterioration of physiological parameters important to keeping an organism alive and healthy. Physical exercise, defined as planned, structured and repetitive physical activity, has been an important force to alter physiology and brain development during the process of human beings' evolution. Among several aspects of aging, the aim of this review is to discuss the balance between two vital cellular processes such as autophagy and apoptosis, based on the fact that physical exercise as a non-pharmacological strategy seems to rescue the imbalance between autophagy and apoptosis during aging. Therefore, the effects of different types or modalities of physical exercise in humans and animals, and the benefits of each of them on aging, will be discussed as a possible preventive strategy against neuronal death.

引用

收藏

页数：16

相关论文

共 229 条

[1]

Aerobic exercise modulates cytokine profile and sleep quality in elderly [J].

Abd El-Kader, Shehab M. ;

Al-Jiffri, Osama H. .

AFRICAN HEALTH SCIENCES, 2019, 19 (02) :2198-2207

[2]

Hippocampal and Cerebral Blood Flow after Exercise Cessation in Master Athletes [J].

Alfini, Alfonso J. ;

Weiss, Lauren R. ;

Leitner, Brooks P. ;

Smith, Theresa J. ;

Hagberg, James M. ;

Smith, J. Carson .

FRONTIERS IN AGING NEUROSCIENCE, 2016, 8

[3]

Effects of mild running on substantia nigra during early neurodegeneration [J].

Almeida, Michael F. ;

Silva, Carolliny M. ;

Chaves, Rodrigo S. ;

Lima, Nathan C. R. ;

Almeida, Renato S. ;

Melo, Karla P. ;

Demasi, Marilene ;

Fernandes, Tiago ;

Oliveira, Edilamar M. ;

Netto, Luis E. S. ;

Cardoso, Sandra M. ;

Ferrari, Merari F. R. .

JOURNAL OF SPORTS SCIENCES, 2018, 36 (12) :1363-1370

[4]

Function of the GH/IGF-1 axis in healthy middle-aged male runners [J].

Ambrosio, MR ;

Valentini, A ;

Trasforini, G ;

Minuto, F ;

Ghigo, E ;

Cella, S ;

Margutti, A ;

Pansini, R ;

Uberti, ECD .

NEUROENDOCRINOLOGY, 1996, 63 (06) :498-503

[5]

Growth hormone and mild exercise in combination increases markedly muscle mass and tetanic tension in old rats [J].

Andersen, NB ;

Andreassen, TT ;

Orskov, H ;

Oxlund, H .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2000, 143 (03) :409-418

[6]

Physical Activity Guidelines Advisory Committee Report, 2008 [J].

不详 .

NUTRITION REVIEWS, 2009, 67 (02) :114-120

[7]

Independent and Interactive Effects of Habitually Ingesting Fermented Milk Products Containing Lactobacillus casei Strain Shirota and of Engaging in Moderate Habitual Daily Physical Activity on the Intestinal Health of Older People [J].

Aoyagi, Yukitoshi ;

Amamoto, Ryuta ;

Park, Sungjin ;

Honda, Yusuke ;

Shimamoto, Kazuhito ;

Kushiro, Akira ;

Tsuji, Hirokazu ;

Matsumoto, Hoshitaka ;

Shimizu, Kensuke ;

Miyazaki, Kouji ;

Matsubara, Satoshi ;

Shepherd, Roy J. .

FRONTIERS IN MICROBIOLOGY, 2019, 10

[8]

Neurogenesis in the aging brain [J].

Apple, Deana M. ;

Solano-Fonseca, Rene ;

Kokovay, Erzsebet .

BIOCHEMICAL PHARMACOLOGY, 2017, 141 :77-85

[9]

Leisure Time Physical Activity and Mortality A Detailed Pooled Analysis of the Dose-Response Relationship [J].

Arem, Hannah ;

Moore, Steven C. ;

Patel, Alpa ;

Hartge, Patricia ;

de Gonzalez, Amy Berrington ;

Visvanathan, Kala ;

Campbell, Peter T. ;

Freedman, Michal ;

Weiderpass, Elisabete ;

Adami, Hans Olov ;

Linet, Martha S. ;

Lee, I. -Min ;

Matthews, Charles E. .

JAMA INTERNAL MEDICINE, 2015, 175 (06) :959-967

[10]

Serum testosterone, growth hormone, and insulin-like growth factor-1 levels, mental reaction time, and maximal aerobic exercise in sedentary and long-term physically trained elderly males [J].

Ari, Z ;

Kutlu, N ;

Uyanik, BS ;

Taneli, F ;

Buyukyazi, G ;

Tavli, T .

INTERNATIONAL JOURNAL OF NEUROSCIENCE, 2004, 114 (05) :623-637

← 1 2 3 4 5 6 7 8 9 10 →