Chromosomal Mutations Responsible for Fluoroquinolone Resistance in Ureaplasma Species in the United States

被引：39

作者：

Xiao, Li ^{[2
]}

Crabb, Donna M. ^{[1
]}

Duffy, Lynn B. ^{[1
]}

Paralanov, Vanya ^{[3
]}

Glass, John I. ^{[3
]}

Waites, Ken B. ^{[1
]}

机构：

[1] Univ Alabama, Dept Pathol, Birmingham, AL 35294 USA

[2] Univ Alabama, Dept Med, Birmingham, AL 35294 USA

[3] J Craig Venter Inst, Rockville, MD USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2012年 / 56卷 / 05期

关键词：

ANTIBIOTIC-RESISTANCE; UREALYTICUM; IDENTIFICATION; MYCOPLASMAS; DISSEMINATION; MECHANISMS; SEROVARS; PARVUM; GENES;

D O I：

10.1128/AAC.06342-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

We sequenced the full lengths of the gyrA, gyrB, parC, and parE genes in 13 fluoroquinolone-resistant Ureaplasma isolates (levofloxacin MICs, 4 to 32 mu g/ml) and 10 susceptible isolates (MICs <= 2 mu g/ml). Mutations were detected in all resistant isolates but in none of the susceptible isolates. The most prevalent mutation was the S83L substitution in the ParC protein. No plasmid-mediated fluoroquinolone resistance genes were detected.

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页码：2780 / 2783

页数：4

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