Incorporation of conformationally constrained phenylalanine derivatives Tic, Sic, Hic and Nic into a cholecystokinin-B/gastrin receptor antagonist

被引：24

作者：

Gibson, SE ^{[1
]}

Guillo, N ^{[1
]}

Kalindjian, SB ^{[1
]}

Tozer, MJ ^{[1
]}

机构：

[1] JAMES BLACK FDN,LONDON SE24 9JE,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(97)00211-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The preparation and biological properties of a conformationally constrained series of cholecystokinin-B/gastrin receptor ligands are described. The 9-membered ring (Nic) derivative was found to be as active at these receptors as an unconstrained phenylalanine analogue. (C) 1997 Elsevier Science Ltd.

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页码：1289 / 1292

页数：4

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