Mechanisms underlying fatigue: a voxel-based morphometric study of chronic fatigue syndrome

被引：154

作者：

Okada, Tomohisa ^{[1
]}

Tanaka, Masaaki ^{[2
]}

Kuratsune, Hirohiko ^{[3
]}

Watanabe, Yasuyoshi ^{[2
]}

Sadato, Norihiro ^{[1
,4
]}

机构：

[1] Natl Inst Physiol Sci, Okazaki, Aichi 4448585, Japan

[2] Osaka City Univ, Grad Sch Med, Dept Physiol, Osaka 5458585, Japan

[3] Kansai Univ Welf Sci, Fac Hlth Sci Welf, Dept Hlth Sci, Kashihara, Osaka 5820026, Japan

[4] JST RISTEX, Minato Ku, Tokyo 1056218, Japan

来源：

BMC NEUROLOGY | 2004年 / 4卷 / 1期

基金：

日本学术振兴会;

关键词：

Multiple Sclerosis; Prefrontal Cortex; Multiple Sclerosis Patient; Chronic Fatigue Syndrome; Dorsolateral Prefrontal Cortex;

D O I：

10.1186/1471-2377-4-14

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Fatigue is a crucial sensation that triggers rest, yet its underlying neuronal mechanisms remain unclear. Intense long-term fatigue is a symptom of chronic fatigue syndrome, which is used as a model to study the mechanisms underlying fatigue. Methods: Using magnetic resonance imaging, we conducted voxel-based morphometry of 16 patients and 49 age-matched healthy control subjects. Results: We found that patients with chronic fatigue syndrome had reduced gray-matter volume in the bilateral prefrontal cortex. Within these areas, the volume reduction in the right prefrontal cortex paralleled the severity of the fatigue of the subjects. Conclusion: These results are consistent with previous reports of an abnormal distribution of acetyl-L-carnitine uptake, which is one of the biochemical markers of chronic fatigue syndrome, in the prefrontal cortex. Thus, the prefrontal cortex might be an important element of the neural system that regulates sensations of fatigue.

引用

页数：6

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