Online MRI guidance for healthy tissue sparing in patients with cervical cancer: An IMRT planning study

Background and purpose: During cervical cancer treatment, target volumes change position and shape due to organ motion and tumour regression. An MRI-accelerator will provide information on these changes by online magnetic resonance imaging (MRI) guidance throughout each treatment fraction. The purpose of this intensity-modulated radiation therapy (IMRT) planning study is to assess the benefit of online MRI guidance in healthy tissue sparing. Materials and methods: Weekly MRI scans of 11 cervical cancer patients were used. We created four IMRT plans per patient, based on these weekly MRI scans, to simulate an online-IMRT approach. We applied a primary and nodal planning target volume (PTV) margin of 4 mm. As reference, we created an IMRT plan based on the pre-treatment MRI scan (pre-IMIRT) using a primary and nodal PTV margin of 15 and 10 mm. The weekly defined bladder, rectum, bowel, and sigmoid contours were evaluated on the online-IMRT and pre-IMRT dose distributions at six dose levels (V10(Gy), V20(Gy), V30(Gy), V40(Gy), V42.8(Gy), and V45(Gy)), Results: Online-IMRT compared to pre-IMIRT significantly reduced the volume of healthy tissue irradiated to all dose levels, except V10(Gy). Conclusions: Online MRI guidance reduces healthy tissue involvement in patients with cervical cancer. (C) 2008 Elsevier Ireland Ltd. All rights reserved.