Non-TH1 cytokines are augmented systematically early in Guillain-Barre syndrome

被引：32

作者：

Press, R ^{[1
]}

Ozenci, V ^{[1
]}

Kouwenhoven, M ^{[1
]}

Link, H ^{[1
]}

机构：

[1] Huddinge Univ Hosp, Karolinska Inst, Dept Neurol, Neuroimmunol Unit, SE-14186 Stockholm, Sweden

来源：

NEUROLOGY | 2002年 / 58卷 / 03期

关键词：

D O I：

10.1212/WNL.58.3.476

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The T(H)1 vs non-T(H)1 cytokine balance in Guillain-Barre syndrome (GBS) is unknown. Using enzyme-linked immunospot (ELISPOT) assays, we observed elevated numbers of interleukin (IL)-6 and IL-10-secreting blood mononuclear cells (BMNC) during the acute phase in untreated patients, low levels of tumor necrosis factor alpha-secreting BMNC in the recovery phase of GBS. Numbers of IL-12p70-secreting BMNC were not affected over the course of GBS. The non-T(H)1 cytokine profile observed early in GBS may explain the self-limited clinical course associated with GBS.

引用

页码：476 / 478

页数：3

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