Dexamethasone decreases the pro- to anti-inflammatory cytokine ratio during cardiac surgery

被引:104
作者
El Azab, SR
Rosseell, PMJ
de Lange, JJ
Groeneveld, ABJ
van Strik, R
van Wijk, EM
Scheffer, GJ
机构
[1] Amphia Hosp, Dept Anaesthesia & Intens Care, NL-4800 RA Breda, Netherlands
[2] Vrije Univ Med Ctr, Dept Anaesthesiol, NL-1007 MB Amsterdam, Netherlands
[3] Vrije Univ Med Ctr, Dept Intens Care, NL-1007 MB Amsterdam, Netherlands
[4] Erasmus Univ, Sch Med, Dept Epidemiol & Biostat, NL-3000 DR Rotterdam, Netherlands
关键词
analgesics anti-inflammatory; steroid; dexamethasone; protein; cytokine;
D O I
10.1093/bja/88.4.496
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Background. Cytokines regulate inflammation associated with cardiopulmonary bypass (CPB). Pro-inflammatory cytokines may cause myocardial dysfunction and haemodynamic instability after CPB, but the release of anti-inflammatory cytokines is potentially protective. We studied the effects of dexamethasone on pro- and anti-inflammatory cytokine responses during coronary artery bypass grafting surgery. Methods. Seventeen patients were studied: nine patients received dexamethasone 100 mg before induction of anaesthesia (group 1) and eight patients acted as controls (group 2). Plasma levels of tumour necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-8, IL-10 and IL-4 were measured perioperatively. Results. TNF-alpha and IL-8 did not increase significantly in group I whereas they increased in group 2 to greater than preoperative values (P<0.05). IL-6 increased in both groups, with lower values in group I than in group 2 (P<0.05). IL-10 increased in both groups, with higher values in group I (P<0.05). IL-4 did not change in group 1 but decreased in group 2 compared with pre-induction values (P<0.05). After surgery, patients in group 2 had tachycardia, hyperthermia, a greater respiratory rate and higher pulmonary artery pressure, and a longer stay in the intensive care unit. Conclusion. Dexamethasone given before cardiac surgery changes circulating cytokines in an anti-inflammatory direction. Postoperative outcome may be improved by inhibition of the systemic inflammatory response.
引用
收藏
页码:496 / 501
页数:6
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