Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels

被引：68

作者：

Shanley, LJ ^{[1
]}

Irving, AJ ^{[1
]}

Rae, MG ^{[1
]}

Ashford, MLJ ^{[1
]}

Harvey, J ^{[1
]}

机构：

[1] Univ Dundee, Ninewells Hosp & Med Sch, Dept Pharmacol & Neurosci, Dundee DD1 9SY, Scotland

来源：

NATURE NEUROSCIENCE | 2002年 / 5卷 / 04期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/nn824

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

[No abstract available]

引用

页码：299 / 300

页数：2

共 13 条

[1] HKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel β subunit family [J].

Behrens, R ;

Nolting, A ;

Reimann, F ;

Schwarz, M ;

Waldschütz, R ;

Pongs, O .

FEBS LETTERS, 2000, 474 (01) :99-106

[2] Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus [J].

Cowley, MA ;

Smart, JL ;

Rubinstein, M ;

Cordán, MG ;

Diano, S ;

Horvath, TL ;

Cone, RD ;

Low, MJ .

NATURE, 2001, 411 (6836) :480-484

[3] CALCIUM AND VOLTAGE DEPENDENCE OF SINGLE CA-2+-ACTIVATED K+ CHANNELS FROM CULTURED HIPPOCAMPAL-NEURONS OF RAT [J].

FRANCIOLINI, F .

BIOCHIMICA ET BIOPHYSICA ACTA, 1988, 943 (03) :419-427

[4] Essential role of phosphoinositide 3-kinase in leptin-induced KATP channel activation in the rat CRI-G1 insulinoma cell line [J].

Harvey, J ;

McKay, NG ;

Walker, KS ;

Van der Kaay, J ;

Downes, CP ;

Ashford, MLJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (07) :4660-4669

[5] Leptin activates ATP-sensitive potassium channels in the rat insulin-secreting cell line, CRI-G1 [J].

Harvey, J ;

McKenna, F ;

Herson, PS ;

Spanswick, D ;

Ashford, MLJ .

JOURNAL OF PHYSIOLOGY-LONDON, 1997, 504 (03) :527-535

[6]

Latorre R, 1989, Acta Physiol Scand Suppl, V582, P13

[7] A neuronal β subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to chavybdotoxin and iberiotoxin [J].

Meera, P ;

Wallner, M ;

Toro, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (10) :5562-5567

[8] Leptin depolarizes rat hypothalamic paraventricular nucleus neurons [J].

Powis, JE ;

Bains, JS ;

Ferguson, AV .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1998, 274 (05) :R1468-R1472

[9] Leptin enhances NMDA receptor function and modulates hippocampal synaptic plasticity [J].

Shanley, LJ ;

Irving, AJ ;

Harvey, J .

JOURNAL OF NEUROSCIENCE, 2001, 21 (24) :art. no.-RC186

[10] Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels [J].

Spanswick, D ;

Smith, MA ;

Groppi, VE ;

Logan, SD ;

Ashford, MLJ .

NATURE, 1997, 390 (6659) :521-525

← 1 2 →