Similarity analysis, synthesis, and bioassay of antibacterial cyclic peptidomimetics

被引：11

作者：

Berhanu, Workalemahu M. ^{[1
]}

Ibrahim, Mohamed A. ^{[1
,2
,3
]}

Pillai, Girinath G. ^{[1
]}

Oliferenko, Alexander A. ^{[1
]}

Khelashvili, Levan ^{[1
]}

Jabeen, Farukh ^{[4
]}

Mirza, Bushra ^{[5
]}

Ansari, Farzana Latif ^{[4
]}

ul-Haq, Ihsan ^{[5
]}

El-Feky, Said A. ^{[2
]}

Katritzky, Alan R. ^{[1
,6
]}

机构：

[1] Univ Florida, Dept Chem, Ctr Heterocycl Cpds, Gainesville, FL 32611 USA

[2] Zagazig Univ, Fac Pharm, Dept Organ Pharmaceut Chem, Zagazig 44519, Egypt

[3] Misr Univ Sci & Technol, Dept Organ Chem, Coll Pharm, Al Motamayez Dist, Egypt

[4] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan

[5] Quaid I Azam Univ, Dept Biochem, Islamabad 45320, Pakistan

[6] King Abdulaziz Univ, Dept Chem, Jeddah 21589, Saudi Arabia

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 8卷

关键词：

antibacterial; cluster analysis; N-acylbenzotriazoles; peptidomimetics; similarity; VANCOMYCIN-RESISTANT ENTEROCOCCI; CHEMICAL-STRUCTURES; CYCLOPEPTIDE ALKALOIDS; CLUSTERING METHOD; PEPTIDE; DERIVATIVES; HOMOPENTAPEPTIDES; CYCLODEPSIPEPTIDES; TUBERACTINOMYCINS; PASTEURELLA;

D O I：

10.3762/bjoc.8.128

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The chemical similarity of antibacterial cyclic peptides and peptidomimetics was studied in order to identify new promising cyclic scaffolds. A large descriptor space coupled with cluster analysis was employed to digitize known antibacterial structures and to gauge the potential of new peptidomimetic macrocycles, which were conveniently synthesized by acylbenzotriazole methodology. Some of the synthesized compounds were tested against an array of microorganisms and showed antibacterial activity against Bordetella bronchistepica, Micrococcus luteus, and Salmonella typhimurium.

引用

页码：1146 / 1160

页数：15

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