Chemical composition, mutagenic and antimutagenic activities of essential oils from (Tunisian) Artemisia campestris and Artemisia herba-alba

被引:51
作者
Aicha, Neffati [2 ]
Ines, Skandrani [2 ]
Mohamed, Ben Sghaier [2 ]
Ines, Bouhlel [2 ]
Soumaya, Kilani [2 ]
Kamel, Ghedira [2 ]
Mohamed, Neffati [3 ]
Imed, Chraief [4 ]
Mohamed, Hammami [4 ]
Leila, Chekir-Ghedira [1 ]
机构
[1] Fac Med Dent Monastir, Lab Biol Mol & Cellulaire, Monastir 5000, Tunisia
[2] Fac Pharm Monastir, Unite Pharmacognosie Biol Mol 99 UR 07 03, Monastir 5000, Tunisia
[3] Inst Reg Arides Medenine, Lab Ecol Pastorale, Medenine 4119, Tunisia
[4] Fac Med Monastir, Lab Biochim USR Spectrometrie Masse, Monastir 5000, Tunisia
关键词
Artemisia campestris; Artemisia herba-alba; Asteraceae; essential oil; beta-pinene; pinocarvone; alpha-copaene; limonene; isoamyl-2-methylbutyrate; mutagenicity; antimutagenicity; Ames test;
D O I
10.1080/10412905.2008.9700061
中图分类号
O69 [应用化学];
学科分类号
081704 [应用化学];
摘要
The essential oil composition from the aerial parts of Artemisia campestris var. glutinosa Gay ex Bess and Artemisia herba-alba Asso (Asteraceae) of Tunisian origin has been studied by GC and GC/MS. The main constituents of the oil from A. campestris collected in Benguerdane (South of Tunisia) were found to be beta-pinene (41.0%), p-cymene (9.9%), alpha-terpinene (7.9%), limonene (6.5%), myrcene (4.1%), beta-phellandrene (3.4%) and a-pinene (3.2%). Whereas the oil from A. herba-alba collected in Tataouine (South of Tunisia) showed, pinocarvone (38.3%), a-copaene (12.18%), limonene (11.0%), isoamyl2-methylbutyrate (19.5%) as major compounds. The mutagenic and antimutagenic activities of the two oils were investigated by the Salmonella typhimurium / microsome assay, with and without addition of an extrinsic metabolic activation system. The oils showed no mutagenicity when tested with Salmonella typhimurium strains TA98 and TA97. On the other hand, we showed that each oil had antimutagenic activity against the carcinogen Benzo (a) pyrene (B[a] P) when tested with TA97 and TA98 assay systems.
引用
收藏
页码:471 / 477
页数:7
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