Pulmonary and vascular pharmacology of sphingosine 1-phosphate

被引：62

作者：

Brinkmann, Volker

Baumruker, Thomas

机构：

[1] Novartis, Biomed Res Inst, Autoimmun & Transplantat, CH-4002 Basel, Switzerland

[2] Novartis Inst BioMed Res, Autoimmun & Transplantat, A-1235 Vienna, Austria

来源：

CURRENT OPINION IN PHARMACOLOGY | 2006年 / 6卷 / 03期

关键词：

D O I：

10.1016/j.coph.2005.12.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Dysregulation of vasomotor tone, endothelial barrier function and imnune cell trafficking are central to the pathology of many lung diseases, including acute lung injury, adult respiratory distress syndrome, chronic obstructive pulmonary disease and asthma There is increasing evidence that the serum sphingolipid sphingosine 1-phosphate and its G-protein-coupled receptors are pivotal not only in the regulation of lymphocyte migration, but also in the maintenance of vascular homeostasis and the preservation of permeability barriers that separate discrete compartments in the lung.

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页码：244 / 250

页数：7

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