Bioactive cembranoids from the Red Sea soft coral Sarcophyton glaucum

被引：22

作者：

Abou El-Ezz, Rania F. ^{[1
]}

Ahmed, Safwat A. ^{[2
]}

Radwan, Mohamed M. ^{[3
,4
]}

Ayoub, Nahla A. ^{[5
]}

Afifi, Manal S. ^{[1
]}

Ross, Samir A. ^{[3
,6
]}

Szymanski, Pawel T. ^{[7
]}

Fahmy, Hesham ^{[7
]}

Khalifa, Sherief I. ^{[8
]}

机构：

[1] Misr Int Univ, Dept Pharmacognosy, Fac Pharm, Cairo, Egypt

[2] Suez Canal Univ, Dept Pharmacognosy, Fac Pharm, Ismailia, Egypt

[3] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA

[4] Univ Alexandria, Fac Pharm, Dept Pharmacognosy, Alexandria, Egypt

[5] Ain Shams Univ, Dept Pharmacognosy, Fac Pharm, Cairo, Egypt

[6] Univ Mississippi, Sch Pharm, Dept Pharmacognosy, University, MS 38677 USA

[7] S Dakota State Univ, Dept Pharmaceut Sci, Coll Pharm, Brookings, SD 57007 USA

[8] Qatar Univ, Coll Pharm, Doha 02713, Qatar

来源：

TETRAHEDRON LETTERS | 2013年 / 54卷 / 08期

关键词：

Sarcophyton glaucum; Cembranoid diterpenes; (1S,4R,13S)-cembra-2E,7E,11E-trien-4,13-diol; Cytotoxicity against melanoma; SKIN TUMOR-DEVELOPMENT; MARINE TERPENES; DITERPENES; CHEMISTRY; TOBACCO; DIOL;

D O I：

10.1016/j.tetlet.2012.12.037

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A chemical investigation of the Red Sea soft coral Sarcophyton glaucum led to the isolation of one new cembranoid diterpene, namely (1S,2E,4R,6E,8S,11R,12S)-8,11-epoxy-4,12-epoxy-2,6-cembradiene (2), two cembranoid diterpenes isolated from Nature for the first time, (1S,2E,4R,6E,8R,11S,12R)-8,12-epoxy-2,6-cembradiene-4,11-diol (3) and (1S,4R,13S)-cembra-2E,7E,11E-trien-4,13-diol (6) as well as three known compounds, sarcophine (1), (+)-7 alpha,8 beta-dihydroxydeepoxysarcophine (4) and sarcophytolide (5). Structure elucidation was achieved using spectroscopic techniques, including ID and 2D-NMR and HRMS. Biological activity investigations of the six isolated compounds were undertaken. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：989 / 992

页数：4

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