The role of phasins in the morphogenesis of poly(3-hydroxybutyrate) granules

被引：32

作者：

Jurasek, L ^{[1
]}

Marchessault, RH ^{[1
]}

机构：

[1] McGill Univ, Dept Chem, Montreal, PQ H3A 2A7, Canada

来源：

BIOMACROMOLECULES | 2002年 / 3卷 / 02期

关键词：

D O I：

10.1021/bm010145d

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent developments in the understanding of the structure of polyhydroxyalkanoate, PHA, granules in bacteria are documented in the literature and point to the role of structural proteins, phasins, in granule formation and stabilization. We have previously conceived a computer program which successfully simulates granule formation in vitro, in the absence of phasins. Now we are extending the computer model to a more complex system, including phasins, to quantify their anticipated effect on the granule properties. The simulation enabled us to propose real experiments to test the validity of the model and provide a framework for a better understanding of PHA granule formation in vivo.

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收藏

页码：256 / 261

页数：6

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